FORMULATION AND DELIVERY ISSUES OF THERAPEUTIC PROTEINS

Sathy V. Balu-Iyer; Razvan D. Miclea; Vivek S. Purohit

doi:10.1002/9780470571224.pse313

FORMULATION AND DELIVERY ISSUES OF THERAPEUTIC PROTEINS

Sathy V. Balu-Iyer
, Razvan D. Miclea
, Vivek S. Purohit

Pharmaceutical Sciences

Roswell Park Cancer Institute
Inc.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The protein therapeutics have unique handling and development requirements relative to the small organic molecule-based drugs and pose exclusive challenges for the formulation scientist. The formulation and delivery issues of therapeutic proteins can contribute to difficulties in pharmaceutical development such as stability, immune toxicity, and pharmacodynamics-related problems. This article focuses on formulation and delivery strategies of therapeutic proteins.

Original language	English
Title of host publication	Pharmaceutical Sciences Encyclopedia
Publisher	wiley
Pages	1-19
Number of pages	19
ISBN (Electronic)	9780470571224
DOIs	https://doi.org/10.1002/9780470571224.pse313
State	Published - Jan 1 2010

Keywords

formulation strategies
protein therapeutics
therapeutic efficacy
viral contamination

Access to Document

10.1002/9780470571224.pse313

Cite this

@inbook{653d3ca8c76a4d46a4e12dcf2c6d2a79,

title = "FORMULATION AND DELIVERY ISSUES OF THERAPEUTIC PROTEINS",

abstract = "The protein therapeutics have unique handling and development requirements relative to the small organic molecule-based drugs and pose exclusive challenges for the formulation scientist. The formulation and delivery issues of therapeutic proteins can contribute to difficulties in pharmaceutical development such as stability, immune toxicity, and pharmacodynamics-related problems. This article focuses on formulation and delivery strategies of therapeutic proteins.",

keywords = "formulation strategies, protein therapeutics, therapeutic efficacy, viral contamination",

author = "Balu-Iyer, \{Sathy V.\} and Miclea, \{Razvan D.\} and Purohit, \{Vivek S.\}",

note = "Publisher Copyright: {\textcopyright} 2010 John Wiley \& Sons, Inc.",

year = "2010",

month = jan,

day = "1",

doi = "10.1002/9780470571224.pse313",

language = "English",

pages = "1--19",

booktitle = "Pharmaceutical Sciences Encyclopedia",

publisher = "wiley",

}

TY - CHAP

T1 - FORMULATION AND DELIVERY ISSUES OF THERAPEUTIC PROTEINS

AU - Balu-Iyer, Sathy V.

AU - Miclea, Razvan D.

AU - Purohit, Vivek S.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The protein therapeutics have unique handling and development requirements relative to the small organic molecule-based drugs and pose exclusive challenges for the formulation scientist. The formulation and delivery issues of therapeutic proteins can contribute to difficulties in pharmaceutical development such as stability, immune toxicity, and pharmacodynamics-related problems. This article focuses on formulation and delivery strategies of therapeutic proteins.

AB - The protein therapeutics have unique handling and development requirements relative to the small organic molecule-based drugs and pose exclusive challenges for the formulation scientist. The formulation and delivery issues of therapeutic proteins can contribute to difficulties in pharmaceutical development such as stability, immune toxicity, and pharmacodynamics-related problems. This article focuses on formulation and delivery strategies of therapeutic proteins.

KW - formulation strategies

KW - protein therapeutics

KW - therapeutic efficacy

KW - viral contamination

UR - https://www.scopus.com/pages/publications/105031329298

U2 - 10.1002/9780470571224.pse313

DO - 10.1002/9780470571224.pse313

M3 - Chapter

AN - SCOPUS:105031329298

SP - 1

EP - 19

BT - Pharmaceutical Sciences Encyclopedia

PB - wiley

ER -

FORMULATION AND DELIVERY ISSUES OF THERAPEUTIC PROTEINS

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this