TY - JOUR
T1 - Folate intake and risk of pancreatic cancer
T2 - Pooled analysis of prospective cohort studies
AU - Bao, Ying
AU - Michaud, Dominique S.
AU - Spiegelman, Donna
AU - Albanes, Demetrius
AU - Anderson, Kristin E.
AU - Bernstein, Leslie
AU - Van Den Brandt, Piet A.
AU - English, Dallas R.
AU - Freudenheim, Jo L.
AU - Fuchs, Charles S.
AU - Giles, Graham G.
AU - Giovannucci, Edward
AU - Goldbohm, R. Alexandra
AU - Håkansson, Niclas
AU - Horn-Ross, Pamela L.
AU - Jacobs, Eric J.
AU - Kitahara, Cari M.
AU - Marshall, James R.
AU - Miller, Anthony B.
AU - Robien, Kim
AU - Rohan, Thomas E.
AU - Schatzkin, Arthur
AU - Stevens, Victoria L.
AU - Stolzenberg-Solomon, Rachael Z.
AU - Virtamo, Jarmo
AU - Wolk, Alicja
AU - Ziegler, Regina G.
AU - Smith-Warner, Stephanie A.
PY - 2010/12/21
Y1 - 2010/12/21
N2 - Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, Ptrend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, Ptrend = .90). No between-study heterogeneity was observed (for dietary folate, Pheterogeneity = .15; for total folate, Pheterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.
AB - Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, Ptrend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, Ptrend = .90). No between-study heterogeneity was observed (for dietary folate, Pheterogeneity = .15; for total folate, Pheterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.
UR - https://www.scopus.com/pages/publications/84856595269
U2 - 10.1093/jnci/djr431
DO - 10.1093/jnci/djr431
M3 - Review article
C2 - 22034634
AN - SCOPUS:84856595269
SN - 0027-8874
VL - 103
SP - 1840
EP - 1850
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 24
ER -