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Fluorescence reactions of fluorescamine with levodopa and its derivatives: Fluorescence assay of 3‐ methoxy‐4‐ hydroxyphenylalanine in levodopa dosage forms

  • SUNY Buffalo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A simple fluorometric method for the quantitation of 3‐methoxy‐4‐hydroxyphenylalanine, either alone or in the presence of levodopa, is presented. Fluorescence is developed by reaction with fluorescamine. The interactions of this reagent with levodopa and a number of its derivatives under various experimental conditions were studied. Negligible fluorescence was obtained with levodopa, dopamine, levodopa benzyl ester, and 6‐hydroxydopamine.

Original languageEnglish
Pages (from-to)839-841
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume64
Issue number5
DOIs
StatePublished - May 1975

Keywords

  • Fluorescamine—reactions with levodopa and derivatives, fluorometry analysis for 3‐methoxy‐4‐hydroxyphenylalanine
  • Fluorometry—reaction of fluorescamine with levodopa and derivatives, analysis for 3‐methoxy‐4‐hydroxyphenylalanine
  • Levodopa and derivatives—reaction with fluorescamine, fluorometric analysis for 3‐methoxy‐4‐hydroxyphenylalanine

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