First total synthesis of sialylated and sulfated Lewis(x) mucin Core 2 structures as potential tumor associated antigens

B. G. Huang; R. K. Jain; R. D. Locke; J. L. Alderfer; W. A. Tabaczynski; K. L. Matta

doi:10.1016/S0040-4039(00)00975-8

First total synthesis of sialylated and sulfated Lewis(x) mucin Core 2 structures as potential tumor associated antigens

B. G. Huang
, R. K. Jain
, R. D. Locke
, J. L. Alderfer
, W. A. Tabaczynski
, K. L. Matta

Department of Chemical and Biological Engineering

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two branched Core 2 structures, (3-O-SO₃Na)Galβ1→4(Fucα1→3)GlcNAcβ1→6(NeuAcα2→3Galβ1→3)Ga1NAcαOMe (1) and its positional isomer NeuAcα2→3Galβ1→4(Fucα1→3)GlcNAcβ1→6(3-OSO₃Na-Galβ1→3)GalNAcαOMe (2), were chemically synthesized for the first time as potential tumor associated antigens. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	6279-6284
Number of pages	6
Journal	Tetrahedron Letters
Volume	41
Issue number	33
DOIs	https://doi.org/10.1016/S0040-4039(00)00975-8
State	Published - Aug 12 2000

Keywords

Antigens
Core 2 structure
Glycosylation
Oligosaccharides

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10.1016/S0040-4039(00)00975-8

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title = "First total synthesis of sialylated and sulfated Lewis(x) mucin Core 2 structures as potential tumor associated antigens",

abstract = "Two branched Core 2 structures, (3-O-SO3Na)Galβ1→4(Fucα1→3)GlcNAcβ1→6(NeuAcα2→3Galβ1→3)Ga1NAcαOMe (1) and its positional isomer NeuAcα2→3Galβ1→4(Fucα1→3)GlcNAcβ1→6(3-OSO3Na-Galβ1→3)GalNAcαOMe (2), were chemically synthesized for the first time as potential tumor associated antigens. (C) 2000 Elsevier Science Ltd.",

keywords = "Antigens, Core 2 structure, Glycosylation, Oligosaccharides",

author = "Huang, \{B. G.\} and Jain, \{R. K.\} and Locke, \{R. D.\} and Alderfer, \{J. L.\} and Tabaczynski, \{W. A.\} and Matta, \{K. L.\}",

year = "2000",

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doi = "10.1016/S0040-4039(00)00975-8",

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TY - JOUR

T1 - First total synthesis of sialylated and sulfated Lewis(x) mucin Core 2 structures as potential tumor associated antigens

AU - Huang, B. G.

AU - Jain, R. K.

AU - Locke, R. D.

AU - Alderfer, J. L.

AU - Tabaczynski, W. A.

AU - Matta, K. L.

PY - 2000/8/12

Y1 - 2000/8/12

N2 - Two branched Core 2 structures, (3-O-SO3Na)Galβ1→4(Fucα1→3)GlcNAcβ1→6(NeuAcα2→3Galβ1→3)Ga1NAcαOMe (1) and its positional isomer NeuAcα2→3Galβ1→4(Fucα1→3)GlcNAcβ1→6(3-OSO3Na-Galβ1→3)GalNAcαOMe (2), were chemically synthesized for the first time as potential tumor associated antigens. (C) 2000 Elsevier Science Ltd.

AB - Two branched Core 2 structures, (3-O-SO3Na)Galβ1→4(Fucα1→3)GlcNAcβ1→6(NeuAcα2→3Galβ1→3)Ga1NAcαOMe (1) and its positional isomer NeuAcα2→3Galβ1→4(Fucα1→3)GlcNAcβ1→6(3-OSO3Na-Galβ1→3)GalNAcαOMe (2), were chemically synthesized for the first time as potential tumor associated antigens. (C) 2000 Elsevier Science Ltd.

KW - Antigens

KW - Core 2 structure

KW - Glycosylation

KW - Oligosaccharides

UR - https://www.scopus.com/pages/publications/0034641453

U2 - 10.1016/S0040-4039(00)00975-8

DO - 10.1016/S0040-4039(00)00975-8

M3 - Article

AN - SCOPUS:0034641453

SN - 0040-4039

VL - 41

SP - 6279

EP - 6284

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

First total synthesis of sialylated and sulfated Lewis(x) mucin Core 2 structures as potential tumor associated antigens

Abstract

Keywords

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