First report of blaVIM-4- and mcr-9-coharboring Enterobacter species isolated from a pediatric patient

Kalyan D. Chavda; Lars F. Westblade; Michael J. Satlin; Andrew C. Hemmert; Mariana Castanheira; Stephen G. Jenkins; Liang Chen; Barry N. Kreiswirth

doi:10.1128/mSphere.00629-19

First report of bla_VIM-4- and mcr-9-coharboring Enterobacter species isolated from a pediatric patient

Kalyan D. Chavda
, Lars F. Westblade
, Michael J. Satlin
, Andrew C. Hemmert
, Mariana Castanheira
, Stephen G. Jenkins
, Liang Chen
, Barry N. Kreiswirth

Pharmacy

Hackensack Meridian Health
Cornell University
BioMerieux
JMI Laboratories

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

An Enterobacter hormaechei isolate harboring bla_VIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The bla_VIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9.

Original language	English
Article number	e00629-19
Journal	mSphere
Volume	4
Issue number	5
DOIs	https://doi.org/10.1128/mSphere.00629-19
State	Published - 2019

Keywords

Carbapenem
Carbapenemase
Colistin
Enterobacter
mcr-9
VIM
VIM-4

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10.1128/mSphere.00629-19

Cite this

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title = "First report of blaVIM-4- and mcr-9-coharboring Enterobacter species isolated from a pediatric patient",

abstract = "An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9.",

keywords = "Carbapenem, Carbapenemase, Colistin, Enterobacter, mcr-9, VIM, VIM-4",

author = "Chavda, \{Kalyan D.\} and Westblade, \{Lars F.\} and Satlin, \{Michael J.\} and Hemmert, \{Andrew C.\} and Mariana Castanheira and Jenkins, \{Stephen G.\} and Liang Chen and Kreiswirth, \{Barry N.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Chavda et al.",

year = "2019",

doi = "10.1128/mSphere.00629-19",

language = "English",

volume = "4",

journal = "mSphere",

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publisher = "American Society for Microbiology",

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T1 - First report of blaVIM-4- and mcr-9-coharboring Enterobacter species isolated from a pediatric patient

AU - Chavda, Kalyan D.

AU - Westblade, Lars F.

AU - Satlin, Michael J.

AU - Hemmert, Andrew C.

AU - Castanheira, Mariana

AU - Jenkins, Stephen G.

AU - Chen, Liang

AU - Kreiswirth, Barry N.

PY - 2019

Y1 - 2019

N2 - An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9.

AB - An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9.

KW - Carbapenem

KW - Carbapenemase

KW - Colistin

KW - Enterobacter

KW - mcr-9

KW - VIM

KW - VIM-4

UR - https://www.scopus.com/pages/publications/85072116709

U2 - 10.1128/mSphere.00629-19

DO - 10.1128/mSphere.00629-19

M3 - Article

C2 - 31511372

AN - SCOPUS:85072116709

SN - 2379-5042

VL - 4

JO - mSphere

JF - mSphere

IS - 5

M1 - e00629-19

ER -

First report of bla_VIM-4- and mcr-9-coharboring Enterobacter species isolated from a pediatric patient

Abstract

Keywords

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