Feeding elicited by dynorphin (1-13) microinjections into the ventral tegmental area in rats

Margaret E. Hamilton; Michael A. Bozarth

doi:10.1016/0024-3205(88)90271-8

Feeding elicited by dynorphin (1-13) microinjections into the ventral tegmental area in rats

Margaret E. Hamilton
, Michael A. Bozarth

Psychology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Both the endogenous opioid peptide, dynorphin (1-13) (DYN), and morphine elicited dose-dependent feeding when microinjected into the ventral tegmental area of food-satiated rats. DYN was 50, 000 times more potent than morphine in producing feeding. Whereas the ED50 for morphine was in the nanomole range, the ED50 for DYN was in the femtomole range. Administration of a narcotic antagonist attenuated DYN-elicited feeding. These data suggest a possible role for DYN in the VTA in opioid modulation of feeding behavior.

Original language	English
Pages (from-to)	941-946
Number of pages	6
Journal	Life Sciences
Volume	43
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(88)90271-8
State	Published - 1988

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title = "Feeding elicited by dynorphin (1-13) microinjections into the ventral tegmental area in rats",

abstract = "Both the endogenous opioid peptide, dynorphin (1-13) (DYN), and morphine elicited dose-dependent feeding when microinjected into the ventral tegmental area of food-satiated rats. DYN was 50, 000 times more potent than morphine in producing feeding. Whereas the ED50 for morphine was in the nanomole range, the ED50 for DYN was in the femtomole range. Administration of a narcotic antagonist attenuated DYN-elicited feeding. These data suggest a possible role for DYN in the VTA in opioid modulation of feeding behavior.",

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year = "1988",

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AU - Hamilton, Margaret E.

AU - Bozarth, Michael A.

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N2 - Both the endogenous opioid peptide, dynorphin (1-13) (DYN), and morphine elicited dose-dependent feeding when microinjected into the ventral tegmental area of food-satiated rats. DYN was 50, 000 times more potent than morphine in producing feeding. Whereas the ED50 for morphine was in the nanomole range, the ED50 for DYN was in the femtomole range. Administration of a narcotic antagonist attenuated DYN-elicited feeding. These data suggest a possible role for DYN in the VTA in opioid modulation of feeding behavior.

AB - Both the endogenous opioid peptide, dynorphin (1-13) (DYN), and morphine elicited dose-dependent feeding when microinjected into the ventral tegmental area of food-satiated rats. DYN was 50, 000 times more potent than morphine in producing feeding. Whereas the ED50 for morphine was in the nanomole range, the ED50 for DYN was in the femtomole range. Administration of a narcotic antagonist attenuated DYN-elicited feeding. These data suggest a possible role for DYN in the VTA in opioid modulation of feeding behavior.

UR - https://www.scopus.com/pages/publications/0023795158

U2 - 10.1016/0024-3205(88)90271-8

DO - 10.1016/0024-3205(88)90271-8

M3 - Article

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AN - SCOPUS:0023795158

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VL - 43

SP - 941

EP - 946

JO - Life Sciences

JF - Life Sciences

IS - 11

ER -

Feeding elicited by dynorphin (1-13) microinjections into the ventral tegmental area in rats

Abstract

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