Feature-based design of bio-degradable micro-patterned structures

This paper presents a novelfeature-based variational modeling to control the bio-degradation process and thus material release kinetics of biodegradable micro-structures. Pattern architecture of micro-structure is varied according to the predetermined degradation profile over the micro-structure based on tissue engineering requirements. Optimum pattern architecture is generated over the micro-structure with varying geometric features and degradation kinetics.Several micro-pattern examples are provided with different patterning features (PFs) and degradation profiles, and their time baseddegradation profilesarecalculated based on the developed biodegradation model. An experimental study of degradation process is also developed to compare a fabricated micro-structured biodegradable material to the developed computational model.