Feasibility of oncology clinical trial-embedded evaluation of social determinants of health

Rahela Aziz-Bose; Daniel J. Zheng; Puja J. Umaretiya; Lenka Ilcisin; Kristen Stevenson; Victoria Koch; Ariana Valenzuela; Peter D. Cole; Lisa M. Gennarini; Justine M. Kahn; Kara M. Kelly; Thai Hoa Tran; Bruno Michon; Jennifer J.G. Welch; Lewis B. Silverman; Joanne Wolfe; Kira Bona

doi:10.1002/pbc.29933

Feasibility of oncology clinical trial-embedded evaluation of social determinants of health

Rahela Aziz-Bose
, Daniel J. Zheng
, Puja J. Umaretiya
, Lenka Ilcisin
, Kristen Stevenson
, Victoria Koch
, Ariana Valenzuela
, Peter D. Cole
, Lisa M. Gennarini
, Justine M. Kahn
, Kara M. Kelly
, Thai Hoa Tran
, Bruno Michon
, Jennifer J.G. Welch
, Lewis B. Silverman
, Joanne Wolfe
, Kira Bona

Pediatrics

Dana-Farber Cancer Institute
Boston Children's Hospital
Harvard University
Children's Hospital of Philadelphia
Brigham and Women’s Hospital
Rutgers - The State University of New Jersey, New Brunswick
Albert Einstein College of Medicine
Columbia University
Sainte-Justine Hospital University Center
Centre de Recherche du Centre Hospitalier de l'Université Laval (CRCHUL)
Brown University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9–93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.

Original language	English
Article number	e29933
Journal	Pediatric Blood and Cancer
Volume	69
Issue number	11
DOIs	https://doi.org/10.1002/pbc.29933
State	Published - Nov 2022

Keywords

health equity
research methods
social determinants of health

Access to Document

10.1002/pbc.29933

Cite this

Aziz-Bose, R., Zheng, D. J., Umaretiya, P. J., Ilcisin, L., Stevenson, K., Koch, V., Valenzuela, A., Cole, P. D., Gennarini, L. M., Kahn, J. M., Kelly, K. M., Tran, T. H., Michon, B., Welch, J. J. G., Silverman, L. B., Wolfe, J., & Bona, K. (2022). Feasibility of oncology clinical trial-embedded evaluation of social determinants of health. Pediatric Blood and Cancer, 69(11), Article e29933. https://doi.org/10.1002/pbc.29933

@article{776a8746cf5145908451362adcdeae87,

title = "Feasibility of oncology clinical trial-embedded evaluation of social determinants of health",

abstract = "Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5\%) opted-in to the embedded SDoH study; 375 (95.7\%) completed baseline surveys, with high longitudinal response rates (88.9–93.1\%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.",

keywords = "health equity, research methods, social determinants of health",

author = "Rahela Aziz-Bose and Zheng, \{Daniel J.\} and Umaretiya, \{Puja J.\} and Lenka Ilcisin and Kristen Stevenson and Victoria Koch and Ariana Valenzuela and Cole, \{Peter D.\} and Gennarini, \{Lisa M.\} and Kahn, \{Justine M.\} and Kelly, \{Kara M.\} and Tran, \{Thai Hoa\} and Bruno Michon and Welch, \{Jennifer J.G.\} and Silverman, \{Lewis B.\} and Joanne Wolfe and Kira Bona",

note = "Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",

year = "2022",

month = nov,

doi = "10.1002/pbc.29933",

language = "English",

volume = "69",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "11",

}

Aziz-Bose, R, Zheng, DJ, Umaretiya, PJ, Ilcisin, L, Stevenson, K, Koch, V, Valenzuela, A, Cole, PD, Gennarini, LM, Kahn, JM, Kelly, KM, Tran, TH, Michon, B, Welch, JJG, Silverman, LB, Wolfe, J & Bona, K 2022, 'Feasibility of oncology clinical trial-embedded evaluation of social determinants of health', Pediatric Blood and Cancer, vol. 69, no. 11, e29933. https://doi.org/10.1002/pbc.29933

TY - JOUR

T1 - Feasibility of oncology clinical trial-embedded evaluation of social determinants of health

AU - Aziz-Bose, Rahela

AU - Zheng, Daniel J.

AU - Umaretiya, Puja J.

AU - Ilcisin, Lenka

AU - Stevenson, Kristen

AU - Koch, Victoria

AU - Valenzuela, Ariana

AU - Cole, Peter D.

AU - Gennarini, Lisa M.

AU - Kahn, Justine M.

AU - Kelly, Kara M.

AU - Tran, Thai Hoa

AU - Michon, Bruno

AU - Welch, Jennifer J.G.

AU - Silverman, Lewis B.

AU - Wolfe, Joanne

AU - Bona, Kira

PY - 2022/11

Y1 - 2022/11

N2 - Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9–93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.

AB - Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9–93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.

KW - health equity

KW - research methods

KW - social determinants of health

UR - https://www.scopus.com/pages/publications/85137608037

U2 - 10.1002/pbc.29933

DO - 10.1002/pbc.29933

M3 - Article

C2 - 36069432

AN - SCOPUS:85137608037

SN - 1545-5009

VL - 69

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 11

M1 - e29933

ER -

Feasibility of oncology clinical trial-embedded evaluation of social determinants of health

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this