Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

Yanan Zhao; Padmaja Paderu; Steven Park; Aleksandra Dukhan; Meredith Senter; David S. Perlin

doi:10.1128/AAC.06163-11

Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

Yanan Zhao
, Padmaja Paderu
, Steven Park
, Aleksandra Dukhan
, Meredith Senter
, David S. Perlin

Pharmacy

Public Health Research Institute, New York

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.

Original language	English
Pages (from-to)	2770-2772
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	5
DOIs	https://doi.org/10.1128/AAC.06163-11
State	Published - May 2012

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abstract = "Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.",

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AU - Zhao, Yanan

AU - Paderu, Padmaja

AU - Park, Steven

AU - Dukhan, Aleksandra

AU - Senter, Meredith

AU - Perlin, David S.

PY - 2012/5

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AB - Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.

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ER -

Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

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