Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum

Brian T. Tsuji; Steven N. Leonard; Paul R. Rhomberg; Ronald N. Jones; Michael J. Rybak

doi:10.1016/j.diagmicrobio.2007.11.011

Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum

Brian T. Tsuji
, Steven N. Leonard
, Paul R. Rhomberg
, Ronald N. Jones
, Michael J. Rybak

Pharmacy

Wayne State University
University Health Center
JMI Laboratories

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.

Original language	English
Pages (from-to)	441-444
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	60
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2007.11.011
State	Published - Apr 2008

Keywords

Antimicrobial effect
Daptomycin
Protein binding
Teicoplanin
Telavancin
Vancomycin

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10.1016/j.diagmicrobio.2007.11.011

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title = "Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum",

abstract = "We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.",

keywords = "Antimicrobial effect, Daptomycin, Protein binding, Teicoplanin, Telavancin, Vancomycin",

author = "Tsuji, \{Brian T.\} and Leonard, \{Steven N.\} and Rhomberg, \{Paul R.\} and Jones, \{Ronald N.\} and Rybak, \{Michael J.\}",

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AU - Tsuji, Brian T.

AU - Leonard, Steven N.

AU - Rhomberg, Paul R.

AU - Jones, Ronald N.

AU - Rybak, Michael J.

PY - 2008/4

Y1 - 2008/4

N2 - We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.

AB - We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.

KW - Antimicrobial effect

KW - Daptomycin

KW - Protein binding

KW - Teicoplanin

KW - Telavancin

KW - Vancomycin

UR - https://www.scopus.com/pages/publications/40749123591

U2 - 10.1016/j.diagmicrobio.2007.11.011

DO - 10.1016/j.diagmicrobio.2007.11.011

M3 - Article

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AN - SCOPUS:40749123591

SN - 0732-8893

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SP - 441

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JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum

Abstract

Keywords

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