Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus

Brian T. Tsuji; Michael J. Rybak; Kerry L. Lau; George Sakoulas

doi:10.1128/AAC.00671-06

Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus

Brian T. Tsuji
, Michael J. Rybak
, Kerry L. Lau
, George Sakoulas

Pharmacy

Wayne State University
University Health Center
New York Medical College

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Simulated therapeutic vancomycin exposures were evaluated against agr wild-type and knockout Staphylococcus aureus groups I, II, III, and IV using an in vitro pharmacodynamic model. All agr groups developed intermediate resistance to vancomycin after subtherapeutic exposure. The free unbound fraction of the area under the concentration-time curve (fAUC/MIC) required to suppress resistance was fourfold higher (P < 0.001) in agr dysfunctional strains (112 to 169) than that in parent wild-type strains (28).

Original language	English
Pages (from-to)	1089-1091
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	3
DOIs	https://doi.org/10.1128/AAC.00671-06
State	Published - Mar 2007

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abstract = "Simulated therapeutic vancomycin exposures were evaluated against agr wild-type and knockout Staphylococcus aureus groups I, II, III, and IV using an in vitro pharmacodynamic model. All agr groups developed intermediate resistance to vancomycin after subtherapeutic exposure. The free unbound fraction of the area under the concentration-time curve (fAUC/MIC) required to suppress resistance was fourfold higher (P < 0.001) in agr dysfunctional strains (112 to 169) than that in parent wild-type strains (28).",

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AU - Sakoulas, George

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Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus

Abstract

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