Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans

Steven A. Rubin; Mikhail Pletnikov; Rolf Taffs; Phil J. Snoy; Darwyn Kobasa; Earl G. Brown; Kathryn E. Wright; Kathryn M. Carbone

doi:10.1128/JVI.74.11.5382-5384.2000

Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans

Steven A. Rubin
, Mikhail Pletnikov
, Rolf Taffs
, Phil J. Snoy
, Darwyn Kobasa
, Earl G. Brown
, Kathryn E. Wright
, Kathryn M. Carbone

Physiology and Biophysics

United States Food and Drug Administration
University of Ottawa
Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

Original language	English
Pages (from-to)	5382-5384
Number of pages	3
Journal	Journal of Virology
Volume	74
Issue number	11
DOIs	https://doi.org/10.1128/JVI.74.11.5382-5384.2000
State	Published - 2000

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10.1128/JVI.74.11.5382-5384.2000

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title = "Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans",

abstract = "Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.",

author = "Rubin, \{Steven A.\} and Mikhail Pletnikov and Rolf Taffs and Snoy, \{Phil J.\} and Darwyn Kobasa and Brown, \{Earl G.\} and Wright, \{Kathryn E.\} and Carbone, \{Kathryn M.\}",

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AU - Rubin, Steven A.

AU - Pletnikov, Mikhail

AU - Taffs, Rolf

AU - Snoy, Phil J.

AU - Kobasa, Darwyn

AU - Brown, Earl G.

AU - Wright, Kathryn E.

AU - Carbone, Kathryn M.

PY - 2000

Y1 - 2000

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AB - Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

UR - https://www.scopus.com/pages/publications/0034109239

U2 - 10.1128/JVI.74.11.5382-5384.2000

DO - 10.1128/JVI.74.11.5382-5384.2000

M3 - Article

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VL - 74

SP - 5382

EP - 5384

JO - Journal of Virology

JF - Journal of Virology

IS - 11

ER -

Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans

Abstract

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