Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner

Rutao Yao; Ranjith M. Ramachandra; Ashish Panse; Deepika Balla; Jianhua Yan; Richard E. Carson

doi:10.1117/12.845323

Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner

Rutao Yao
, Ranjith M. Ramachandra
, Ashish Panse
, Deepika Balla
, Jianhua Yan
, Richard E. Carson

Radiology

SUNY Buffalo
Yale University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We previously designed a component based 3-D PSF model to obtain a compact yet accurate system matrix for a dedicated human brain PET scanner. In this work, we adapted the model to a small animal PET scanner. Based on the model, we derived the system matrix for back-to-back gamma source in air, fluorine-I 8 and iodine- 124 source in water by Monte Carlo simulation. The characteristics of the PSF model were evaluated and the performance of the newly derived system matrix was assessed by comparing its reconstructed images with the established reconstruction program provided on the animal PET scanner. The new system matrix showed strong PSF dependency on the line-of-response (LOR) incident angle and LOR depth. This confirmed the validity of the two components selected for the model. The effect of positron range on the system matrix was observed by comparing the PSFs of different isotopes. A simulated and an experimental hot-rod phantom study showed that the reconstruction with the proposed system matrix achieved better resolution recovery as compared to the algorithm provided by the manufacturer. Quantitative evaluation also showed better convergence to the expected contrast value at similar noise level. In conclusion, it has been shown that the system matrix derivation method is applicable to the animal PET system studied, suggesting that the method may be used for other PET systems and different isotope applications.

Original language	English
Title of host publication	Medical Imaging 2010
Subtitle of host publication	Physics of Medical Imaging
Edition	PART 1
DOIs	https://doi.org/10.1117/12.845323
State	Published - 2010
Event	Medical Imaging 2010: Physics of Medical Imaging - San Diego, CA, United States Duration: Feb 15 2010 → Feb 18 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Number	PART 1
Volume	7622
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2010: Physics of Medical Imaging
Country/Territory	United States
City	San Diego, CA
Period	02/15/10 → 02/18/10

Keywords

Image reconstruction
Monte Carlo simulation
PET
System matrix

Access to Document

10.1117/12.845323

Cite this

Yao, R., Ramachandra, R. M., Panse, A., Balla, D., Yan, J., & Carson, R. E. (2010). Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner. In Medical Imaging 2010: Physics of Medical Imaging (PART 1 ed.). Article 76220W (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7622, No. PART 1). https://doi.org/10.1117/12.845323

@inproceedings{e439948bbc384b87a6d808886c9777f2,

title = "Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner",

abstract = "We previously designed a component based 3-D PSF model to obtain a compact yet accurate system matrix for a dedicated human brain PET scanner. In this work, we adapted the model to a small animal PET scanner. Based on the model, we derived the system matrix for back-to-back gamma source in air, fluorine-I 8 and iodine- 124 source in water by Monte Carlo simulation. The characteristics of the PSF model were evaluated and the performance of the newly derived system matrix was assessed by comparing its reconstructed images with the established reconstruction program provided on the animal PET scanner. The new system matrix showed strong PSF dependency on the line-of-response (LOR) incident angle and LOR depth. This confirmed the validity of the two components selected for the model. The effect of positron range on the system matrix was observed by comparing the PSFs of different isotopes. A simulated and an experimental hot-rod phantom study showed that the reconstruction with the proposed system matrix achieved better resolution recovery as compared to the algorithm provided by the manufacturer. Quantitative evaluation also showed better convergence to the expected contrast value at similar noise level. In conclusion, it has been shown that the system matrix derivation method is applicable to the animal PET system studied, suggesting that the method may be used for other PET systems and different isotope applications.",

keywords = "Image reconstruction, Monte Carlo simulation, PET, System matrix",

author = "Rutao Yao and Ramachandra, \{Ranjith M.\} and Ashish Panse and Deepika Balla and Jianhua Yan and Carson, \{Richard E.\}",

year = "2010",

doi = "10.1117/12.845323",

language = "English",

isbn = "9780819480231",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

number = "PART 1",

booktitle = "Medical Imaging 2010",

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note = "Medical Imaging 2010: Physics of Medical Imaging ; Conference date: 15-02-2010 Through 18-02-2010",

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Yao, R, Ramachandra, RM, Panse, A, Balla, D, Yan, J & Carson, RE 2010, Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner. in Medical Imaging 2010: Physics of Medical Imaging. PART 1 edn, 76220W, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, no. PART 1, vol. 7622, Medical Imaging 2010: Physics of Medical Imaging, San Diego, CA, United States, 02/15/10. https://doi.org/10.1117/12.845323

Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner. / Yao, Rutao; Ramachandra, Ranjith M.; Panse, Ashish et al.
Medical Imaging 2010: Physics of Medical Imaging. PART 1. ed. 2010. 76220W (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7622, No. PART 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ramachandra, Ranjith M.

AU - Panse, Ashish

AU - Balla, Deepika

AU - Yan, Jianhua

AU - Carson, Richard E.

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N2 - We previously designed a component based 3-D PSF model to obtain a compact yet accurate system matrix for a dedicated human brain PET scanner. In this work, we adapted the model to a small animal PET scanner. Based on the model, we derived the system matrix for back-to-back gamma source in air, fluorine-I 8 and iodine- 124 source in water by Monte Carlo simulation. The characteristics of the PSF model were evaluated and the performance of the newly derived system matrix was assessed by comparing its reconstructed images with the established reconstruction program provided on the animal PET scanner. The new system matrix showed strong PSF dependency on the line-of-response (LOR) incident angle and LOR depth. This confirmed the validity of the two components selected for the model. The effect of positron range on the system matrix was observed by comparing the PSFs of different isotopes. A simulated and an experimental hot-rod phantom study showed that the reconstruction with the proposed system matrix achieved better resolution recovery as compared to the algorithm provided by the manufacturer. Quantitative evaluation also showed better convergence to the expected contrast value at similar noise level. In conclusion, it has been shown that the system matrix derivation method is applicable to the animal PET system studied, suggesting that the method may be used for other PET systems and different isotope applications.

AB - We previously designed a component based 3-D PSF model to obtain a compact yet accurate system matrix for a dedicated human brain PET scanner. In this work, we adapted the model to a small animal PET scanner. Based on the model, we derived the system matrix for back-to-back gamma source in air, fluorine-I 8 and iodine- 124 source in water by Monte Carlo simulation. The characteristics of the PSF model were evaluated and the performance of the newly derived system matrix was assessed by comparing its reconstructed images with the established reconstruction program provided on the animal PET scanner. The new system matrix showed strong PSF dependency on the line-of-response (LOR) incident angle and LOR depth. This confirmed the validity of the two components selected for the model. The effect of positron range on the system matrix was observed by comparing the PSFs of different isotopes. A simulated and an experimental hot-rod phantom study showed that the reconstruction with the proposed system matrix achieved better resolution recovery as compared to the algorithm provided by the manufacturer. Quantitative evaluation also showed better convergence to the expected contrast value at similar noise level. In conclusion, it has been shown that the system matrix derivation method is applicable to the animal PET system studied, suggesting that the method may be used for other PET systems and different isotope applications.

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KW - Monte Carlo simulation

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KW - System matrix

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M3 - Conference contribution

AN - SCOPUS:84873889637

SN - 9780819480231

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2010

T2 - Medical Imaging 2010: Physics of Medical Imaging

Y2 - 15 February 2010 through 18 February 2010

ER -

Evaluation of a 3-D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner

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Keywords

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