Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Karen M. Palaszynski; Hongbiao Liu; Kyi Kyi Loo; Rhonda R. Voskuhl

doi:10.1016/j.jneuroim.2003.12.015

Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Karen M. Palaszynski
, Hongbiao Liu
, Kyi Kyi Loo
, Rhonda R. Voskuhl

Neurology

University of California at Los Angeles

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERα and ERβ, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS.

Original language	English
Pages (from-to)	84-89
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	149
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2003.12.015
State	Published - Apr 2004

Keywords

Cytokines
Estrogen
Experimental autoimmune encephalomyelitis
Males
Multiple sclerosis

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10.1016/j.jneuroim.2003.12.015

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title = "Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: Implications for multiple sclerosis",

abstract = "Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERα and ERβ, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS.",

keywords = "Cytokines, Estrogen, Experimental autoimmune encephalomyelitis, Males, Multiple sclerosis",

author = "Palaszynski, \{Karen M.\} and Hongbiao Liu and Loo, \{Kyi Kyi\} and Voskuhl, \{Rhonda R.\}",

year = "2004",

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T1 - Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis

T2 - Implications for multiple sclerosis

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AU - Liu, Hongbiao

AU - Loo, Kyi Kyi

AU - Voskuhl, Rhonda R.

PY - 2004/4

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N2 - Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERα and ERβ, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS.

AB - Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERα and ERβ, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS.

KW - Cytokines

KW - Estrogen

KW - Experimental autoimmune encephalomyelitis

KW - Males

KW - Multiple sclerosis

UR - https://www.scopus.com/pages/publications/1542396010

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M3 - Article

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AN - SCOPUS:1542396010

SN - 0165-5728

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

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Keywords

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