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Estimating Tumor Growth Rates In Vivo

  • Duke University

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

In this paper, we develop methods for inferring tumor growth rates from the observation of tumor volumes at two time points. We fit power law, exponential, Gompertz, and Spratt’s generalized logistic model to five data sets. Though the data sets are small and there are biases due to the way the samples were ascertained, there is a clear sign of exponential growth for the breast and liver cancers, and a 2/3’s power law (surface growth) for the two neurological cancers.

Original languageEnglish
Pages (from-to)1934-1954
Number of pages21
JournalBulletin of Mathematical Biology
Volume77
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Gompertz
  • Logistic
  • Power law growth
  • Tumor growth kinetics

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