Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents

Guang Zhu Jin; Young Jae You; Yong Kim; Nguyen Hai Nam; Byung Zun Ahn

doi:10.1016/S0223-5234(01)01229-6

Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents

Guang Zhu Jin
, Young Jae You
, Yong Kim
, Nguyen Hai Nam
, Byung Zun Ahn

Pharmaceutical Sciences

Yanbian University
Chungnam National University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED₅₀, <6 μg mL^-1) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more active in vivo than chlorambucil (T/C, 168%).

Original language	English
Pages (from-to)	361-366
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/S0223-5234(01)01229-6
State	Published - 2001

Keywords

Anthraquinone
Antitumor
Chlorambucil
Cytotoxicity
Ester
Structure-activity relationship

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10.1016/S0223-5234(01)01229-6

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title = "Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents",

abstract = "Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED50, <6 μg mL-1) and derivatives 1 and 12 (T/C, 200 and 205\%) appeared more active in vivo than chlorambucil (T/C, 168\%).",

keywords = "Anthraquinone, Antitumor, Chlorambucil, Cytotoxicity, Ester, Structure-activity relationship",

author = "Jin, \{Guang Zhu\} and You, \{Young Jae\} and Yong Kim and Nam, \{Nguyen Hai\} and Ahn, \{Byung Zun\}",

year = "2001",

doi = "10.1016/S0223-5234(01)01229-6",

language = "English",

volume = "36",

pages = "361--366",

journal = "European Journal of Medicinal Chemistry",

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TY - JOUR

T1 - Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents

AU - Jin, Guang Zhu

AU - You, Young Jae

AU - Kim, Yong

AU - Nam, Nguyen Hai

AU - Ahn, Byung Zun

PY - 2001

Y1 - 2001

N2 - Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED50, <6 μg mL-1) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more active in vivo than chlorambucil (T/C, 168%).

AB - Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED50, <6 μg mL-1) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more active in vivo than chlorambucil (T/C, 168%).

KW - Anthraquinone

KW - Antitumor

KW - Chlorambucil

KW - Cytotoxicity

KW - Ester

KW - Structure-activity relationship

UR - https://www.scopus.com/pages/publications/0034926062

U2 - 10.1016/S0223-5234(01)01229-6

DO - 10.1016/S0223-5234(01)01229-6

M3 - Article

C2 - 11461761

AN - SCOPUS:0034926062

SN - 0223-5234

VL - 36

SP - 361

EP - 366

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 4

ER -

Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents

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Keywords

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