Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents

Guang Zhu Jin; Young Jae You; Byung Zun Ahn

doi:10.1016/S0960-894X(01)00260-8

Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents

Guang Zhu Jin
, Young Jae You
, Byung Zun Ahn

Pharmaceutical Sciences

Yanbian University
Chungnam National University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Eight esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone with melphalan were prepared and tested for their antitumor activity (S-180) and cytotoxicity. 2-{1-[4-(p-Bis(2-chloroethyl)-aminophenyl)-butanoyloxy]methyl}-1,4- dihydroxy-9,10-anthraquinone and 2-{1-[4-(p-bis(2-chloroethyl)-aminophenyl)-butanoyloxy]ethyl}-1,4-dihydroxy- 9,10-anthraquinone showed remarkable antitumor activity (T/C, 265 and 272%).

Original language	English
Pages (from-to)	1473-1476
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(01)00260-8
State	Published - Jun 4 2001

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title = "Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents",

abstract = "Eight esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone with melphalan were prepared and tested for their antitumor activity (S-180) and cytotoxicity. 2-\{1-[4-(p-Bis(2-chloroethyl)-aminophenyl)-butanoyloxy]methyl\}-1,4- dihydroxy-9,10-anthraquinone and 2-\{1-[4-(p-bis(2-chloroethyl)-aminophenyl)-butanoyloxy]ethyl\}-1,4-dihydroxy- 9,10-anthraquinone showed remarkable antitumor activity (T/C, 265 and 272\%).",

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doi = "10.1016/S0960-894X(01)00260-8",

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T1 - Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents

AU - Jin, Guang Zhu

AU - You, Young Jae

AU - Ahn, Byung Zun

PY - 2001/6/4

Y1 - 2001/6/4

N2 - Eight esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone with melphalan were prepared and tested for their antitumor activity (S-180) and cytotoxicity. 2-{1-[4-(p-Bis(2-chloroethyl)-aminophenyl)-butanoyloxy]methyl}-1,4- dihydroxy-9,10-anthraquinone and 2-{1-[4-(p-bis(2-chloroethyl)-aminophenyl)-butanoyloxy]ethyl}-1,4-dihydroxy- 9,10-anthraquinone showed remarkable antitumor activity (T/C, 265 and 272%).

AB - Eight esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone with melphalan were prepared and tested for their antitumor activity (S-180) and cytotoxicity. 2-{1-[4-(p-Bis(2-chloroethyl)-aminophenyl)-butanoyloxy]methyl}-1,4- dihydroxy-9,10-anthraquinone and 2-{1-[4-(p-bis(2-chloroethyl)-aminophenyl)-butanoyloxy]ethyl}-1,4-dihydroxy- 9,10-anthraquinone showed remarkable antitumor activity (T/C, 265 and 272%).

UR - https://www.scopus.com/pages/publications/0035806173

U2 - 10.1016/S0960-894X(01)00260-8

DO - 10.1016/S0960-894X(01)00260-8

M3 - Article

C2 - 11378380

AN - SCOPUS:0035806173

SN - 0960-894X

VL - 11

SP - 1473

EP - 1476

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents

Abstract

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