Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes

Justin R. Denton; Dinesh Sukumaran; Huw M.L. Davies

doi:10.1021/ol070714f

Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes

Justin R. Denton
, Dinesh Sukumaran
, Huw M.L. Davies

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Equation Presented The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh ₂(R-PTAD) ₄, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88->98%).

Original language	English
Pages (from-to)	2625-2628
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	14
DOIs	https://doi.org/10.1021/ol070714f
State	Published - Jul 5 2007

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@article{8a166260b4884d4fa502c9ae8c271bca,

title = "Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes",

abstract = "Equation Presented The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh 2(R-PTAD) 4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94\%) and enantioselectivity (88->98\%).",

author = "Denton, \{Justin R.\} and Dinesh Sukumaran and Davies, \{Huw M.L.\}",

year = "2007",

month = jul,

day = "5",

doi = "10.1021/ol070714f",

language = "English",

volume = "9",

pages = "2625--2628",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes

AU - Denton, Justin R.

AU - Sukumaran, Dinesh

AU - Davies, Huw M.L.

PY - 2007/7/5

Y1 - 2007/7/5

N2 - Equation Presented The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh 2(R-PTAD) 4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88->98%).

AB - Equation Presented The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh 2(R-PTAD) 4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88->98%).

UR - https://www.scopus.com/pages/publications/34547490082

U2 - 10.1021/ol070714f

DO - 10.1021/ol070714f

M3 - Article

AN - SCOPUS:34547490082

SN - 1523-7060

VL - 9

SP - 2625

EP - 2628

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -

Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes

Abstract

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