Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan

Yi Tsung Lin; Chien Chuang; Sheng Hua Chou; Chih Han Juan; Tsuey Ching Yang; Barry N. Kreiswirth; Liang Chen

doi:10.1007/s10096-023-04733-3

Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan

Yi Tsung Lin
, Chien Chuang
, Sheng Hua Chou
, Chih Han Juan
, Tsuey Ching Yang
, Barry N. Kreiswirth
, Liang Chen

Pharmacy

Veterans General Hospital-Taipei
National Yang Ming Chiao Tung University
Hackensack Meridian Health

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla _OXA-48.

Original language	English
Pages (from-to)	389-393
Number of pages	5
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	43
Issue number	2
DOIs	https://doi.org/10.1007/s10096-023-04733-3
State	Published - Feb 2024

Keywords

Carbapenemase
Hypervirulent strain
OXA-48

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10.1007/s10096-023-04733-3

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title = "Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan",

abstract = "The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48.",

keywords = "Carbapenemase, Hypervirulent strain, OXA-48",

author = "Lin, \{Yi Tsung\} and Chien Chuang and Chou, \{Sheng Hua\} and Juan, \{Chih Han\} and Yang, \{Tsuey Ching\} and Kreiswirth, \{Barry N.\} and Liang Chen",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2024",

month = feb,

doi = "10.1007/s10096-023-04733-3",

language = "English",

volume = "43",

pages = "389--393",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

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T1 - Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan

AU - Lin, Yi Tsung

AU - Chuang, Chien

AU - Chou, Sheng Hua

AU - Juan, Chih Han

AU - Yang, Tsuey Ching

AU - Kreiswirth, Barry N.

AU - Chen, Liang

PY - 2024/2

Y1 - 2024/2

N2 - The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48.

AB - The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48.

KW - Carbapenemase

KW - Hypervirulent strain

KW - OXA-48

UR - https://www.scopus.com/pages/publications/85178896623

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DO - 10.1007/s10096-023-04733-3

M3 - Article

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AN - SCOPUS:85178896623

SN - 0934-9723

VL - 43

SP - 389

EP - 393

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

IS - 2

ER -

Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan

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Keywords

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