Elevated platelet intracellular calcium concentration in bipolar depression

Steven L. Dubovsky; Chul Lee; Jennifer Christiano; James Murphy

doi:10.1016/0006-3223(91)90266-O

Elevated platelet intracellular calcium concentration in bipolar depression

Steven L. Dubovsky
, Chul Lee
, Jennifer Christiano
, James Murphy

Department of Psychiatry

University of Colorado Anschutz Medical Campus
The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Baseline and thrombin-stimulated free intracellular calcium concentrations in blood platelets were significantly higher in untreated depressed bipolar patients than in untreated unipolar depressed patients or controls. Platelet intracellular calcium ion concentrations in euthymic-treated bipolar patients were equivalent to control values, suggesting but not proving a state-dependent change in intracellular calcium ion dynamics in bipolar depression. Unipolar and some subsets of bipolar patients appear not to exhibit this change.

Original language	English
Pages (from-to)	441-450
Number of pages	10
Journal	Biological Psychiatry
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/0006-3223(91)90266-O
State	Published - Mar 1 1991

Access to Document

10.1016/0006-3223(91)90266-O

Cite this

@article{328e81cb68c843878a35d296128a4230,

title = "Elevated platelet intracellular calcium concentration in bipolar depression",

abstract = "Baseline and thrombin-stimulated free intracellular calcium concentrations in blood platelets were significantly higher in untreated depressed bipolar patients than in untreated unipolar depressed patients or controls. Platelet intracellular calcium ion concentrations in euthymic-treated bipolar patients were equivalent to control values, suggesting but not proving a state-dependent change in intracellular calcium ion dynamics in bipolar depression. Unipolar and some subsets of bipolar patients appear not to exhibit this change.",

author = "Dubovsky, \{Steven L.\} and Chul Lee and Jennifer Christiano and James Murphy",

year = "1991",

month = mar,

day = "1",

doi = "10.1016/0006-3223(91)90266-O",

language = "English",

volume = "29",

pages = "441--450",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Elevated platelet intracellular calcium concentration in bipolar depression

AU - Dubovsky, Steven L.

AU - Lee, Chul

AU - Christiano, Jennifer

AU - Murphy, James

PY - 1991/3/1

Y1 - 1991/3/1

N2 - Baseline and thrombin-stimulated free intracellular calcium concentrations in blood platelets were significantly higher in untreated depressed bipolar patients than in untreated unipolar depressed patients or controls. Platelet intracellular calcium ion concentrations in euthymic-treated bipolar patients were equivalent to control values, suggesting but not proving a state-dependent change in intracellular calcium ion dynamics in bipolar depression. Unipolar and some subsets of bipolar patients appear not to exhibit this change.

AB - Baseline and thrombin-stimulated free intracellular calcium concentrations in blood platelets were significantly higher in untreated depressed bipolar patients than in untreated unipolar depressed patients or controls. Platelet intracellular calcium ion concentrations in euthymic-treated bipolar patients were equivalent to control values, suggesting but not proving a state-dependent change in intracellular calcium ion dynamics in bipolar depression. Unipolar and some subsets of bipolar patients appear not to exhibit this change.

UR - https://www.scopus.com/pages/publications/0025758913

U2 - 10.1016/0006-3223(91)90266-O

DO - 10.1016/0006-3223(91)90266-O

M3 - Article

C2 - 2018817

AN - SCOPUS:0025758913

SN - 0006-3223

VL - 29

SP - 441

EP - 450

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 5

ER -

Elevated platelet intracellular calcium concentration in bipolar depression

Abstract

Access to Document

Other files and links

Fingerprint

Cite this