Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

Byoung Soo Kim; Min Ku Kim; Younghak Cho; Eman E. Hamed; Martha U. Gillette; Hyeongyun Cha; Nenad Miljkovic; Vinay K. Aakalu; Kai Kang; Kyung No Son; Kyle M. Schachtschneider; Lawrence B. Schook; Chenfei Hu; Gabriel Popescu; Yeonsoo Park; William C. Ballance; Seunggun Yu; Sung Gap Im; Jonghwi Lee; Chi Hwan Lee; Hyunjoon Kong

doi:10.1126/sciadv.abc5630

Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

Byoung Soo Kim
, Min Ku Kim
, Younghak Cho
, Eman E. Hamed
, Martha U. Gillette
, Hyeongyun Cha
, Nenad Miljkovic
, Vinay K. Aakalu
, Kai Kang
, Kyung No Son
, Kyle M. Schachtschneider
, Lawrence B. Schook
, Chenfei Hu
, Gabriel Popescu
, Yeonsoo Park
, William C. Ballance
, Seunggun Yu
, Sung Gap Im
, Jonghwi Lee
, Chi Hwan Lee

Hyunjoon Kong

Department of Mechanical and Aerospace Engineering

University of Illinois at Urbana-Champaign
Purdue University
Korea Advanced Institute of Science and Technology
Kyushu University
University of Illinois at Chicago
The University of Chicago
Korea Electrotechnology Research Institute
Chung-Ang University
Yonsei University

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

“Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod’s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.

Original language	English
Article number	eabc5630
Journal	Science Advances
Volume	6
Issue number	42
DOIs	https://doi.org/10.1126/sciadv.abc5630
State	Published - Oct 2020

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Kim, B. S., Kim, M. K., Cho, Y., Hamed, E. E., Gillette, M. U., Cha, H., Miljkovic, N., Aakalu, V. K., Kang, K., Son, K. N., Schachtschneider, K. M., Schook, L. B., Hu, C., Popescu, G., Park, Y., Ballance, W. C., Yu, S., Im, S. G., Lee, J., ... Kong, H. (2020). Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices. Science Advances, 6(42), Article eabc5630. https://doi.org/10.1126/sciadv.abc5630

@article{cc4967487f314f07852a8c0b1d445a96,

title = "Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices",

abstract = "“Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod{\textquoteright}s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.",

author = "Kim, \{Byoung Soo\} and Kim, \{Min Ku\} and Younghak Cho and Hamed, \{Eman E.\} and Gillette, \{Martha U.\} and Hyeongyun Cha and Nenad Miljkovic and Aakalu, \{Vinay K.\} and Kai Kang and Son, \{Kyung No\} and Schachtschneider, \{Kyle M.\} and Schook, \{Lawrence B.\} and Chenfei Hu and Gabriel Popescu and Yeonsoo Park and Ballance, \{William C.\} and Seunggun Yu and Im, \{Sung Gap\} and Jonghwi Lee and Lee, \{Chi Hwan\} and Hyunjoon Kong",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 The Authors, some rights reserved;",

year = "2020",

month = oct,

doi = "10.1126/sciadv.abc5630",

language = "English",

volume = "6",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "42",

}

Kim, BS, Kim, MK, Cho, Y, Hamed, EE, Gillette, MU, Cha, H, Miljkovic, N, Aakalu, VK, Kang, K, Son, KN, Schachtschneider, KM, Schook, LB, Hu, C, Popescu, G, Park, Y, Ballance, WC, Yu, S, Im, SG, Lee, J, Lee, CH & Kong, H 2020, 'Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices', Science Advances, vol. 6, no. 42, eabc5630. https://doi.org/10.1126/sciadv.abc5630

TY - JOUR

T1 - Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

AU - Kim, Byoung Soo

AU - Kim, Min Ku

AU - Cho, Younghak

AU - Hamed, Eman E.

AU - Gillette, Martha U.

AU - Cha, Hyeongyun

AU - Miljkovic, Nenad

AU - Aakalu, Vinay K.

AU - Kang, Kai

AU - Son, Kyung No

AU - Schachtschneider, Kyle M.

AU - Schook, Lawrence B.

AU - Hu, Chenfei

AU - Popescu, Gabriel

AU - Park, Yeonsoo

AU - Ballance, William C.

AU - Yu, Seunggun

AU - Im, Sung Gap

AU - Lee, Jonghwi

AU - Lee, Chi Hwan

AU - Kong, Hyunjoon

PY - 2020/10

Y1 - 2020/10

N2 - “Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod’s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.

AB - “Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod’s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.

UR - https://www.scopus.com/pages/publications/85093705373

U2 - 10.1126/sciadv.abc5630

DO - 10.1126/sciadv.abc5630

M3 - Article

C2 - 33067233

AN - SCOPUS:85093705373

SN - 2375-2548

VL - 6

JO - Science Advances

JF - Science Advances

IS - 42

M1 - eabc5630

ER -

Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

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