Efficient method for the synthesis of bisaminoethanethiols and their pyrrole conjugates

By following the protection and deprotection approach, an efficient method for the preparation of bisaminoethanethiol ligands (N₂S₂) is discussed. In our attempts to synthesize certain nonpeptide analogs of neurotensin, moldel studies were performed by using these ligands for preparing the corresponding pyrrole based conjugates. This methodology provides an alternate approach for developing various target specific agents that cross the blood brain barrier.