Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles

Mi Yang; Honglin Jin; Juan Chen; Lili Ding; Kenneth K. Ng; Qiaoya Lin; Jonathan F. Lovell; Zhihong Zhang; Gang Zheng

doi:10.1002/smll.201001589

Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles

Mi Yang
, Honglin Jin
, Juan Chen
, Lili Ding
, Kenneth K. Ng
, Qiaoya Lin
, Jonathan F. Lovell
, Zhihong Zhang
, Gang Zheng

Department of Biomedical Engineering

University Health Network
University of Toronto
Nanjing Drum Tower Hospital
Huazhong University of Science and Technology

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

High-density lipoprotein (HDL)-mimicking peptide-phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability of cholesterol-modified siRNA displayed by the nanoparticle results in the selective delivery of RNA interference (RNAi) to targeted cells. This provides a strategy to bypass endolysosomal trafficking, and makes HPPS a useful tool for therapeutic siRNA delivery.

Original language	English
Pages (from-to)	568-573
Number of pages	6
Journal	Small
Volume	7
Issue number	5
DOIs	https://doi.org/10.1002/smll.201001589
State	Published - Mar 7 2011

Keywords

biomimetics
cancer therapy
cytosolic delivery
nanoparticles
siRNA

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10.1002/smll.201001589

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AU - Yang, Mi

AU - Jin, Honglin

AU - Chen, Juan

AU - Ding, Lili

AU - Ng, Kenneth K.

AU - Lin, Qiaoya

AU - Lovell, Jonathan F.

AU - Zhang, Zhihong

AU - Zheng, Gang

PY - 2011/3/7

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AB - High-density lipoprotein (HDL)-mimicking peptide-phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability of cholesterol-modified siRNA displayed by the nanoparticle results in the selective delivery of RNA interference (RNAi) to targeted cells. This provides a strategy to bypass endolysosomal trafficking, and makes HPPS a useful tool for therapeutic siRNA delivery.

KW - biomimetics

KW - cancer therapy

KW - cytosolic delivery

KW - nanoparticles

KW - siRNA

UR - https://www.scopus.com/pages/publications/79952216980

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ER -

Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles

Abstract

Keywords

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