Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat

Rosemary Dziak; Dorothy J. Rowe; M. J. Brown; E. Hausmann

doi:10.1016/0003-9969(82)90031-0

Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat

Rosemary Dziak
, Dorothy J. Rowe
, M. J. Brown
, E. Hausmann

Department of Oral Biology

University of Iowa

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Synthetic N-acetyl-muramyl-l-alanyl-d-isoglutamine (MDP) stimulated the release of ⁴⁵Ca from fetal rat long bones in culture for 48 h and also increased the number of osteoclasts per bone and the number of nuclei per osteoclast. It also increased calcium uptake in enriched populations of osteoclasts obtained by sequential collagenase digestions of newborn rat calvaria. This effect was observed after a 120 min incubation with 10^-6 M MDP. Effects of MDP on calcium uptake in osteoblasts were not consistently observed. No effects on cyclic AMP were noted in either osteoclast or osteoblast populations treated with MDP for periods from 1-120 min at 37 °C.

Original language	English
Pages (from-to)	787-791
Number of pages	5
Journal	Archives of Oral Biology
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/0003-9969(82)90031-0
State	Published - 1982

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title = "Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat",

abstract = "Synthetic N-acetyl-muramyl-l-alanyl-d-isoglutamine (MDP) stimulated the release of 45Ca from fetal rat long bones in culture for 48 h and also increased the number of osteoclasts per bone and the number of nuclei per osteoclast. It also increased calcium uptake in enriched populations of osteoclasts obtained by sequential collagenase digestions of newborn rat calvaria. This effect was observed after a 120 min incubation with 10-6 M MDP. Effects of MDP on calcium uptake in osteoblasts were not consistently observed. No effects on cyclic AMP were noted in either osteoclast or osteoblast populations treated with MDP for periods from 1-120 min at 37 °C.",

author = "Rosemary Dziak and Rowe, \{Dorothy J.\} and Brown, \{M. J.\} and E. Hausmann",

year = "1982",

doi = "10.1016/0003-9969(82)90031-0",

language = "English",

volume = "27",

pages = "787--791",

journal = "Archives of Oral Biology",

issn = "0003-9969",

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T1 - Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat

AU - Dziak, Rosemary

AU - Rowe, Dorothy J.

AU - Brown, M. J.

AU - Hausmann, E.

PY - 1982

Y1 - 1982

N2 - Synthetic N-acetyl-muramyl-l-alanyl-d-isoglutamine (MDP) stimulated the release of 45Ca from fetal rat long bones in culture for 48 h and also increased the number of osteoclasts per bone and the number of nuclei per osteoclast. It also increased calcium uptake in enriched populations of osteoclasts obtained by sequential collagenase digestions of newborn rat calvaria. This effect was observed after a 120 min incubation with 10-6 M MDP. Effects of MDP on calcium uptake in osteoblasts were not consistently observed. No effects on cyclic AMP were noted in either osteoclast or osteoblast populations treated with MDP for periods from 1-120 min at 37 °C.

AB - Synthetic N-acetyl-muramyl-l-alanyl-d-isoglutamine (MDP) stimulated the release of 45Ca from fetal rat long bones in culture for 48 h and also increased the number of osteoclasts per bone and the number of nuclei per osteoclast. It also increased calcium uptake in enriched populations of osteoclasts obtained by sequential collagenase digestions of newborn rat calvaria. This effect was observed after a 120 min incubation with 10-6 M MDP. Effects of MDP on calcium uptake in osteoblasts were not consistently observed. No effects on cyclic AMP were noted in either osteoclast or osteoblast populations treated with MDP for periods from 1-120 min at 37 °C.

UR - https://www.scopus.com/pages/publications/0020453226

U2 - 10.1016/0003-9969(82)90031-0

DO - 10.1016/0003-9969(82)90031-0

M3 - Article

C2 - 6297436

AN - SCOPUS:0020453226

SN - 0003-9969

VL - 27

SP - 787

EP - 791

JO - Archives of Oral Biology

JF - Archives of Oral Biology

IS - 10

ER -

Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat

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