Effects of noise on inferior colliculus evoked potentials and cochlear anatomy in young and aged chinchillas

Like many aging humans, the aging chinchilla tends to lose high- frequency sensitivity at a faster rate than low-frequency sensitivity. This feature, combined with its excellent low-frequency hearing, makes the chinchilla attractive as an animal model for studying the relationship between noise-induced hearing loss (NIHL) and age-related hearing loss (AHL). In the present study, we examined susceptibility to noise in 15 aged (10-15 years old) and 15 young chinchillas. Two levels of noise were used, with the aim of determining whether age-related differences exist in the magnitude and rate of recovery from temporary threshold shifts produced by a moderate- level (95 dB) noise exposure, or in susceptibility to permanent threshold shifts and cochlear damage caused by a highlevel (106 dB) noise exposure. Thresholds and response amplitudes at 0.5, 1, 2, 4, 8 and 16 kHz were determined from evoked potentials recorded from the inferior colliculus. Cochlear histology was performed on animals exposed to high-level noise. The results suggest that older animals are equally vulnerable to moderate-level noise, but may be slightly more vulnerable to high-level noise. For moderate- level exposures, there appears to be a simple additive relationship (in dB) between AHL and NIHL. For highlevel exposures, the relationship may be more complex.