Abstract
Two-month-old Wistar rats ingested 10% ethanol for 12 months. Their parotid glands were then compared with those of normal controls by light microscopy. They had extensive ductal and acinar oncocytic transformation; numerous atypical acinar cells showed anisocytosis, polyploidism and hyperchromatism, features that were absent in controls. Oncocytosis and atypical acinar cells have been reported in 2-3-yr-old ('senile') Wistar rats. Thus, chronic alcohol ingestion may produce cellular features resembling those observed in the parotid gland of 'senile' Wistar rats.
| Original language | English |
|---|---|
| Pages (from-to) | 69-72 |
| Number of pages | 4 |
| Journal | Archives of Oral Biology |
| Volume | 37 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1992 |
Keywords
- ageing
- alcohol
- alcoholism
- cellular pleomorphism
- chronic
- histology
- morphology
- oncocytosis
- parotid glands
- rat
- senescence
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