Effects of Ca2+ channel ligands on [3H]QNB binding at m1 and m3 muscarinic receptors

Yong Wha Kwon; David J. Triggle

doi:10.1016/0306-3623(91)90445-C

Effects of Ca²⁺ channel ligands on [³H]QNB binding at m₁ and m₃ muscarinic receptors

Yong Wha Kwon
, David J. Triggle

School of Pharmacy and Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

1. 1. The effects of Ca²⁺ channel ligands on [³H]QNB binding in m₁- or m₃-transfected Chinese hamster ovary (CHO) cells have been studied. 2. 2. The IC₅₀ values of Ca²⁺ channel ligands for the inhibition of [³H]QNB binding were between 10^-6 and 10^-4 M and the rank order of potency was HOE 166 > McN 6186 > nicardipine > tiamdipine > verapamil > diltiazem > Bay K 8644 > nifedipine at m₁ and m₃ receptors. 3. 3. The results indicate that Ca²⁺ channel ligands employed in this experiment do not distinguish subtypes of muscarinic receptors.

Original language	English
Pages (from-to)	267-270
Number of pages	4
Journal	General Pharmacology: The Vascular System
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0306-3623(91)90445-C
State	Published - 1991

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title = "Effects of Ca2+ channel ligands on [3H]QNB binding at m1 and m3 muscarinic receptors",

abstract = "1. 1. The effects of Ca2+ channel ligands on [3H]QNB binding in m1- or m3-transfected Chinese hamster ovary (CHO) cells have been studied. 2. 2. The IC50 values of Ca2+ channel ligands for the inhibition of [3H]QNB binding were between 10-6 and 10-4 M and the rank order of potency was HOE 166 > McN 6186 > nicardipine > tiamdipine > verapamil > diltiazem > Bay K 8644 > nifedipine at m1 and m3 receptors. 3. 3. The results indicate that Ca2+ channel ligands employed in this experiment do not distinguish subtypes of muscarinic receptors.",

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doi = "10.1016/0306-3623(91)90445-C",

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AU - Kwon, Yong Wha

AU - Triggle, David J.

PY - 1991

Y1 - 1991

N2 - 1. 1. The effects of Ca2+ channel ligands on [3H]QNB binding in m1- or m3-transfected Chinese hamster ovary (CHO) cells have been studied. 2. 2. The IC50 values of Ca2+ channel ligands for the inhibition of [3H]QNB binding were between 10-6 and 10-4 M and the rank order of potency was HOE 166 > McN 6186 > nicardipine > tiamdipine > verapamil > diltiazem > Bay K 8644 > nifedipine at m1 and m3 receptors. 3. 3. The results indicate that Ca2+ channel ligands employed in this experiment do not distinguish subtypes of muscarinic receptors.

AB - 1. 1. The effects of Ca2+ channel ligands on [3H]QNB binding in m1- or m3-transfected Chinese hamster ovary (CHO) cells have been studied. 2. 2. The IC50 values of Ca2+ channel ligands for the inhibition of [3H]QNB binding were between 10-6 and 10-4 M and the rank order of potency was HOE 166 > McN 6186 > nicardipine > tiamdipine > verapamil > diltiazem > Bay K 8644 > nifedipine at m1 and m3 receptors. 3. 3. The results indicate that Ca2+ channel ligands employed in this experiment do not distinguish subtypes of muscarinic receptors.

UR - https://www.scopus.com/pages/publications/4243937790

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DO - 10.1016/0306-3623(91)90445-C

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SN - 0306-3623

VL - 22

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EP - 270

JO - General Pharmacology: The Vascular System

JF - General Pharmacology: The Vascular System

IS - 2

ER -

Effects of Ca²⁺ channel ligands on [³H]QNB binding at m₁ and m₃ muscarinic receptors

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