Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients

Ester Sepúlveda; Isolde G. Rojas; Ursula Brethauer; Nancy P. Maulén; Mirna Muñoz; Lilian Kirsten; Angel Oñate; Eduardo Fernández; Patricia Le Fort; Jaime Rojas

doi:10.1016/j.tripleo.2007.12.035

Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients

Ester Sepúlveda
, Isolde G. Rojas
, Ursula Brethauer
, Nancy P. Maulén
, Mirna Muñoz
, Lilian Kirsten
, Angel Oñate
, Eduardo Fernández
, Patricia Le Fort
, Jaime Rojas

Department of Periodontics and Endodontics

Universidad de Concepción
Universidad Católica de la Santísima Concepción
Regional Hospital of Concepción “Dr. Guillermo Grant Benavente”

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: The objective of this study was to assess if there is increased herpes simplex virus type 1 (HSV-1) salivary shedding in oncology pediatric patients with severe cytopenia (SC). Study design: HSV-1 was detected by real time PCR in saliva samples from oncology pediatric patients (n = 30) during SC and relative cytopenia (RC), and from healthy children (n = 27). Results: The frequency of HSV-1 positive saliva samples was higher in patients with SC as compared to controls (P < .05), and this frequency presented a significant reduction during RC periods (P < .02). The SC group positive for HSV-1 presented both a twofold increase in the neutrophil-to-lymphocyte ratio as compared with SC patients negative for HSV-1 (P < .05), and a positive correlation between neutrophil and lymphocyte counts (P < .05, R = 0.82, R² = 0.67). This correlation was not found in oncology patients negative for HSV-1 during SC and RC. Conclusion: Severe cytopenia in oncology pediatric patients could be an important susceptibility factor for increased HSV-1 salivary shedding.

Original language	English
Pages (from-to)	583-588
Number of pages	6
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume	105
Issue number	5
DOIs	https://doi.org/10.1016/j.tripleo.2007.12.035
State	Published - May 2008

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10.1016/j.tripleo.2007.12.035

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Sepúlveda, E., Rojas, I. G., Brethauer, U., Maulén, N. P., Muñoz, M., Kirsten, L., Oñate, A., Fernández, E., Le Fort, P., & Rojas, J. (2008). Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 105(5), 583-588. https://doi.org/10.1016/j.tripleo.2007.12.035

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title = "Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients",

abstract = "Objective: The objective of this study was to assess if there is increased herpes simplex virus type 1 (HSV-1) salivary shedding in oncology pediatric patients with severe cytopenia (SC). Study design: HSV-1 was detected by real time PCR in saliva samples from oncology pediatric patients (n = 30) during SC and relative cytopenia (RC), and from healthy children (n = 27). Results: The frequency of HSV-1 positive saliva samples was higher in patients with SC as compared to controls (P < .05), and this frequency presented a significant reduction during RC periods (P < .02). The SC group positive for HSV-1 presented both a twofold increase in the neutrophil-to-lymphocyte ratio as compared with SC patients negative for HSV-1 (P < .05), and a positive correlation between neutrophil and lymphocyte counts (P < .05, R = 0.82, R2 = 0.67). This correlation was not found in oncology patients negative for HSV-1 during SC and RC. Conclusion: Severe cytopenia in oncology pediatric patients could be an important susceptibility factor for increased HSV-1 salivary shedding.",

author = "Ester Sep{\'u}lveda and Rojas, \{Isolde G.\} and Ursula Brethauer and Maul{\'e}n, \{Nancy P.\} and Mirna Mu{\~n}oz and Lilian Kirsten and Angel O{\~n}ate and Eduardo Fern{\'a}ndez and \{Le Fort\}, Patricia and Jaime Rojas",

year = "2008",

month = may,

doi = "10.1016/j.tripleo.2007.12.035",

language = "English",

volume = "105",

pages = "583--588",

journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics",

issn = "1079-2104",

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}

Sepúlveda, E, Rojas, IG, Brethauer, U, Maulén, NP, Muñoz, M, Kirsten, L, Oñate, A, Fernández, E, Le Fort, P & Rojas, J 2008, 'Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 105, no. 5, pp. 583-588. https://doi.org/10.1016/j.tripleo.2007.12.035

Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients. / Sepúlveda, Ester; Rojas, Isolde G.; Brethauer, Ursula et al.
In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 105, No. 5, 05.2008, p. 583-588.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients

AU - Sepúlveda, Ester

AU - Rojas, Isolde G.

AU - Brethauer, Ursula

AU - Maulén, Nancy P.

AU - Muñoz, Mirna

AU - Kirsten, Lilian

AU - Oñate, Angel

AU - Fernández, Eduardo

AU - Le Fort, Patricia

AU - Rojas, Jaime

PY - 2008/5

Y1 - 2008/5

N2 - Objective: The objective of this study was to assess if there is increased herpes simplex virus type 1 (HSV-1) salivary shedding in oncology pediatric patients with severe cytopenia (SC). Study design: HSV-1 was detected by real time PCR in saliva samples from oncology pediatric patients (n = 30) during SC and relative cytopenia (RC), and from healthy children (n = 27). Results: The frequency of HSV-1 positive saliva samples was higher in patients with SC as compared to controls (P < .05), and this frequency presented a significant reduction during RC periods (P < .02). The SC group positive for HSV-1 presented both a twofold increase in the neutrophil-to-lymphocyte ratio as compared with SC patients negative for HSV-1 (P < .05), and a positive correlation between neutrophil and lymphocyte counts (P < .05, R = 0.82, R2 = 0.67). This correlation was not found in oncology patients negative for HSV-1 during SC and RC. Conclusion: Severe cytopenia in oncology pediatric patients could be an important susceptibility factor for increased HSV-1 salivary shedding.

AB - Objective: The objective of this study was to assess if there is increased herpes simplex virus type 1 (HSV-1) salivary shedding in oncology pediatric patients with severe cytopenia (SC). Study design: HSV-1 was detected by real time PCR in saliva samples from oncology pediatric patients (n = 30) during SC and relative cytopenia (RC), and from healthy children (n = 27). Results: The frequency of HSV-1 positive saliva samples was higher in patients with SC as compared to controls (P < .05), and this frequency presented a significant reduction during RC periods (P < .02). The SC group positive for HSV-1 presented both a twofold increase in the neutrophil-to-lymphocyte ratio as compared with SC patients negative for HSV-1 (P < .05), and a positive correlation between neutrophil and lymphocyte counts (P < .05, R = 0.82, R2 = 0.67). This correlation was not found in oncology patients negative for HSV-1 during SC and RC. Conclusion: Severe cytopenia in oncology pediatric patients could be an important susceptibility factor for increased HSV-1 salivary shedding.

UR - https://www.scopus.com/pages/publications/42949155137

U2 - 10.1016/j.tripleo.2007.12.035

DO - 10.1016/j.tripleo.2007.12.035

M3 - Article

C2 - 18442743

AN - SCOPUS:42949155137

SN - 1079-2104

VL - 105

SP - 583

EP - 588

JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

IS - 5

ER -

Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients

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