Abstract
The effect of dialyzable transfer factor therapy on 3 patients with immunodeficiency disease and in one patient who demonstrated no evidence of deficiency of either humoral or cellular immunity was studied. Evidence for nonspecificity in the effect of transfer factor on mixed lymphocyte culture reactivity was found. The data suggest that in patients with immunodeficiency disease a maturation of lymphocytes may lead to a generalized increased immune responsiveness. More profoundly, the data show that transfer factor may induce changes in the expression of histocompatibility determinants. Changes were observed in the expression of determinants capable of stimulating in the mixed lymphocyte culture reaction as well as an increase in the capacity of lymphocytes to respond.
| Original language | English |
|---|---|
| Pages (from-to) | 867-871 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1974 |
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