Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms

A. H. Teixeira; E. S. Pereira; L. K.A. Rodrigues; D. Saxena; S. Duarte; I. C.J. Zanin

doi:10.1159/000341190

Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms

A. H. Teixeira
, E. S. Pereira
, L. K.A. Rodrigues
, D. Saxena
, S. Duarte
, I. C.J. Zanin

Restorative Dentistry Administration

Universidade Federal do Ceará
Medical School
New York University

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S⁺L⁺) and control (S^-L^-, S⁺L^-, S ^-L⁺) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S⁺L⁺ or S^-L^- groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.

Original language	English
Pages (from-to)	549-554
Number of pages	6
Journal	Caries Research
Volume	46
Issue number	6
DOIs	https://doi.org/10.1159/000341190
State	Published - Dec 2012

Keywords

Biofilms
In situ study
Photodynamic antimicrobial chemotherapy
Streptococcus mutans

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10.1159/000341190

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title = "Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms",

abstract = "Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S -L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.",

keywords = "Biofilms, In situ study, Photodynamic antimicrobial chemotherapy, Streptococcus mutans",

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year = "2012",

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doi = "10.1159/000341190",

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T1 - Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms

AU - Teixeira, A. H.

AU - Pereira, E. S.

AU - Rodrigues, L. K.A.

AU - Saxena, D.

AU - Duarte, S.

AU - Zanin, I. C.J.

PY - 2012/12

Y1 - 2012/12

N2 - Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S -L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.

AB - Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S -L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.

KW - Biofilms

KW - In situ study

KW - Photodynamic antimicrobial chemotherapy

KW - Streptococcus mutans

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DO - 10.1159/000341190

M3 - Article

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AN - SCOPUS:84865285710

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SP - 549

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JO - Caries Research

JF - Caries Research

IS - 6

ER -

Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms

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