Effect of Phenytoin on Protein Binding of Valproic Acid

J. Bruni; J. M. Gallo; B. J. Wilder

doi:10.1017/S0317167100023878

Effect of Phenytoin on Protein Binding of Valproic Acid

J. Bruni
, J. M. Gallo
, B. J. Wilder

Pharmaceutical Sciences

University of Florida

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.

Original language	English
Pages (from-to)	453-454
Number of pages	2
Journal	Canadian Journal of Neurological Sciences
Volume	6
Issue number	4
DOIs	https://doi.org/10.1017/S0317167100023878
State	Published - Nov 1979

Access to Document

10.1017/S0317167100023878

Cite this

@article{09ca2f3b54114ec0bea85b357e483d11,

title = "Effect of Phenytoin on Protein Binding of Valproic Acid",

abstract = "In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.",

author = "J. Bruni and Gallo, \{J. M.\} and Wilder, \{B. J.\}",

year = "1979",

month = nov,

doi = "10.1017/S0317167100023878",

language = "English",

volume = "6",

pages = "453--454",

journal = "Canadian Journal of Neurological Sciences",

issn = "0317-1671",

publisher = "Cambridge University Press",

number = "4",

}

TY - JOUR

T1 - Effect of Phenytoin on Protein Binding of Valproic Acid

AU - Bruni, J.

AU - Gallo, J. M.

AU - Wilder, B. J.

PY - 1979/11

Y1 - 1979/11

N2 - In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.

AB - In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.

UR - https://www.scopus.com/pages/publications/0018643477

U2 - 10.1017/S0317167100023878

DO - 10.1017/S0317167100023878

M3 - Article

C2 - 120756

AN - SCOPUS:0018643477

SN - 0317-1671

VL - 6

SP - 453

EP - 454

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

IS - 4

ER -

Effect of Phenytoin on Protein Binding of Valproic Acid

Abstract

Access to Document

Other files and links

Fingerprint

Cite this