Effect of Hyperglycemia and Insulin in Acute Coronary Syndromes

Paresh Dandona; Ajay Chaudhuri; Husam Ghanim; Priya Mohanty

doi:10.1016/j.amjcard.2007.04.004

Effect of Hyperglycemia and Insulin in Acute Coronary Syndromes

Medicine

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Previously published data clearly demonstrate that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those undergoing coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in these patients. In this article, we discuss data that demonstrate a proinflammatory effect of glucose and free fatty acids and an anti-inflammatory effect of insulin. We also provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusion in hospitalized patients.

Original language	English
Pages (from-to)	S12-S18
Journal	American Journal of Cardiology
Volume	99
Issue number	11 SUPPL.
DOIs	https://doi.org/10.1016/j.amjcard.2007.04.004
State	Published - Jun 4 2007

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abstract = "Previously published data clearly demonstrate that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those undergoing coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in these patients. In this article, we discuss data that demonstrate a proinflammatory effect of glucose and free fatty acids and an anti-inflammatory effect of insulin. We also provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusion in hospitalized patients.",

author = "Paresh Dandona and Ajay Chaudhuri and Husam Ghanim and Priya Mohanty",

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AU - Chaudhuri, Ajay

AU - Ghanim, Husam

AU - Mohanty, Priya

PY - 2007/6/4

Y1 - 2007/6/4

N2 - Previously published data clearly demonstrate that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those undergoing coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in these patients. In this article, we discuss data that demonstrate a proinflammatory effect of glucose and free fatty acids and an anti-inflammatory effect of insulin. We also provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusion in hospitalized patients.

AB - Previously published data clearly demonstrate that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those undergoing coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in these patients. In this article, we discuss data that demonstrate a proinflammatory effect of glucose and free fatty acids and an anti-inflammatory effect of insulin. We also provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusion in hospitalized patients.

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Effect of Hyperglycemia and Insulin in Acute Coronary Syndromes

Abstract

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