Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue

Andrew H. Talal; Craig E. Irwin; Douglas T. Dieterich; Herman Yee; Linqi Zhang

doi:10.1097/00126334-200103010-00002

Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue

Andrew H. Talal
, Craig E. Irwin
, Douglas T. Dieterich
, Herman Yee
, Linqi Zhang

Medicine

Aaron Diamond AIDS Research Center
New York University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: To determine the change in the percentage of proliferative and activated lymphocytes in gut-associated lymphoid tissue (GALT) in HIV-1-infected subjects compared with that in uninfected controls. Methods: We measured the percentage of proliferative (Ki-67⁺) and activated (CD-69⁺, HLA-DR⁺, CD45RO⁺) lymphocytes from GALT and peripheral blood in chronically HIV-1-infected (12) and uninfected (9) individuals. Results: The percentage of proliferative GALT CD4⁺ T cells was increased in HIV-1-infected control subjects compared with that in uninfected controls (p < .007). Based on immunohistochemical staining, proliferative T cells were principally located in the parafollicular area surrounding lymphoid aggregates. The percentage of activated GALT lymphocytes, however, was not significantly different in HIV-1-infected individuals, whereas it was significantly increased in the peripheral blood of HIV-1-infected individuals. The percentage of peripheral blood lymphocytes trafficking to the intestine was also not significantly different in HIV-1-infected individuals compared with that in uninfected controls. Conclusions: CD4⁺ T cell proliferation in GALT is increased in HIV-1 infection without a significant alteration in the percentage of peripheral blood T cells trafficking to the gastrointestinal mucosa.

Original language	English
Pages (from-to)	208-217
Number of pages	10
Journal	Journal of Acquired Immune Deficiency Syndromes (1999)
Volume	26
Issue number	3
DOIs	https://doi.org/10.1097/00126334-200103010-00002
State	Published - Mar 1 2001

Keywords

CD4 T cell proliferation
Gastrointestinal system
Intestinal mucosa
Ki-67 antigen
T cell activation antigens

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10.1097/00126334-200103010-00002

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title = "Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue",

abstract = "Objective: To determine the change in the percentage of proliferative and activated lymphocytes in gut-associated lymphoid tissue (GALT) in HIV-1-infected subjects compared with that in uninfected controls. Methods: We measured the percentage of proliferative (Ki-67+) and activated (CD-69+, HLA-DR+, CD45RO+) lymphocytes from GALT and peripheral blood in chronically HIV-1-infected (12) and uninfected (9) individuals. Results: The percentage of proliferative GALT CD4+ T cells was increased in HIV-1-infected control subjects compared with that in uninfected controls (p < .007). Based on immunohistochemical staining, proliferative T cells were principally located in the parafollicular area surrounding lymphoid aggregates. The percentage of activated GALT lymphocytes, however, was not significantly different in HIV-1-infected individuals, whereas it was significantly increased in the peripheral blood of HIV-1-infected individuals. The percentage of peripheral blood lymphocytes trafficking to the intestine was also not significantly different in HIV-1-infected individuals compared with that in uninfected controls. Conclusions: CD4+ T cell proliferation in GALT is increased in HIV-1 infection without a significant alteration in the percentage of peripheral blood T cells trafficking to the gastrointestinal mucosa.",

keywords = "CD4 T cell proliferation, Gastrointestinal system, Intestinal mucosa, Ki-67 antigen, T cell activation antigens",

author = "Talal, \{Andrew H.\} and Irwin, \{Craig E.\} and Dieterich, \{Douglas T.\} and Herman Yee and Linqi Zhang",

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AU - Talal, Andrew H.

AU - Irwin, Craig E.

AU - Dieterich, Douglas T.

AU - Yee, Herman

AU - Zhang, Linqi

PY - 2001/3/1

Y1 - 2001/3/1

N2 - Objective: To determine the change in the percentage of proliferative and activated lymphocytes in gut-associated lymphoid tissue (GALT) in HIV-1-infected subjects compared with that in uninfected controls. Methods: We measured the percentage of proliferative (Ki-67+) and activated (CD-69+, HLA-DR+, CD45RO+) lymphocytes from GALT and peripheral blood in chronically HIV-1-infected (12) and uninfected (9) individuals. Results: The percentage of proliferative GALT CD4+ T cells was increased in HIV-1-infected control subjects compared with that in uninfected controls (p < .007). Based on immunohistochemical staining, proliferative T cells were principally located in the parafollicular area surrounding lymphoid aggregates. The percentage of activated GALT lymphocytes, however, was not significantly different in HIV-1-infected individuals, whereas it was significantly increased in the peripheral blood of HIV-1-infected individuals. The percentage of peripheral blood lymphocytes trafficking to the intestine was also not significantly different in HIV-1-infected individuals compared with that in uninfected controls. Conclusions: CD4+ T cell proliferation in GALT is increased in HIV-1 infection without a significant alteration in the percentage of peripheral blood T cells trafficking to the gastrointestinal mucosa.

AB - Objective: To determine the change in the percentage of proliferative and activated lymphocytes in gut-associated lymphoid tissue (GALT) in HIV-1-infected subjects compared with that in uninfected controls. Methods: We measured the percentage of proliferative (Ki-67+) and activated (CD-69+, HLA-DR+, CD45RO+) lymphocytes from GALT and peripheral blood in chronically HIV-1-infected (12) and uninfected (9) individuals. Results: The percentage of proliferative GALT CD4+ T cells was increased in HIV-1-infected control subjects compared with that in uninfected controls (p < .007). Based on immunohistochemical staining, proliferative T cells were principally located in the parafollicular area surrounding lymphoid aggregates. The percentage of activated GALT lymphocytes, however, was not significantly different in HIV-1-infected individuals, whereas it was significantly increased in the peripheral blood of HIV-1-infected individuals. The percentage of peripheral blood lymphocytes trafficking to the intestine was also not significantly different in HIV-1-infected individuals compared with that in uninfected controls. Conclusions: CD4+ T cell proliferation in GALT is increased in HIV-1 infection without a significant alteration in the percentage of peripheral blood T cells trafficking to the gastrointestinal mucosa.

KW - CD4 T cell proliferation

KW - Gastrointestinal system

KW - Intestinal mucosa

KW - Ki-67 antigen

KW - T cell activation antigens

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Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue

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