Abstract
The effect of pimozide on stimulation-induced feeding was tested in food satiated rats. Pimozide produced a dose-dependent decrease in the number of animals eating during electrical stimulation of the lateral hypothalamus. A quantal dose-response analysis yielded an ED50 of 0.323 mg/kg for pimozide. Because this dose is within the range of pimozide doses found to be effective disrupting feeding in other tests, it seems likely that the neural substrate mediating stimulation-induced feeding is similar to that involved in deprivation-induced feeding.
| Original language | English |
|---|---|
| Pages (from-to) | 521-524 |
| Number of pages | 4 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1987 |
Keywords
- Dopamine
- ED50
- Feeding
- Lateral hypothalamus
- Pimozide
- Probit analysis
- Quantal dose-response
- Stimulation-induced feeding
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