Effect of carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid and blood

D. G. Davies; S. L. Britton; G. H. Gurtner; R. E. Dutton; J. A. Krasney

doi:10.1016/0014-4886(84)90067-0

Effect of carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid and blood

D. G. Davies
, S. L. Britton
, G. H. Gurtner
, R. E. Dutton
, J. A. Krasney

Physiology and Biophysics

Texas Tech University Health Sciences Center

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of cerebral carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid (CSF) and blood (PD) was studied in anesthetized dogs by perfusing the ventriculocisternal system with artificial CSF containing the carbonic anhydrase inhibitor, acetazolamide. The slope of the PD vs. arterial blood pH ( ΔPD ΔpHa) was calculated from PD and pHa values obtained during room-air breathing, respiratory acidosis, and respiratory alkalosis. ΔPD ΔpHa decreased from -26.3 ± 1.9 millivolts per pH unit ( mV U) before acetazolamide administration to 17.6 ± 2.1 after acetazolamide (P < 0.02). The PD at pH 7.4 (PD_7.4) increased slightly from 2.9 ± 0.5 mV before acetazolamide treatment to 3.9 ± 0.6 after acetazolamide (P < 0.02). The results suggest that carbonic anhydrase could be involved in generating the PD between CSF and blood.

Original language	English
Pages (from-to)	66-72
Number of pages	7
Journal	Experimental Neurology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(84)90067-0
State	Published - Oct 1984

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title = "Effect of carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid and blood",

abstract = "The effect of cerebral carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid (CSF) and blood (PD) was studied in anesthetized dogs by perfusing the ventriculocisternal system with artificial CSF containing the carbonic anhydrase inhibitor, acetazolamide. The slope of the PD vs. arterial blood pH ( ΔPD ΔpHa) was calculated from PD and pHa values obtained during room-air breathing, respiratory acidosis, and respiratory alkalosis. ΔPD ΔpHa decreased from -26.3 ± 1.9 millivolts per pH unit ( mV U) before acetazolamide administration to 17.6 ± 2.1 after acetazolamide (P < 0.02). The PD at pH 7.4 (PD7.4) increased slightly from 2.9 ± 0.5 mV before acetazolamide treatment to 3.9 ± 0.6 after acetazolamide (P < 0.02). The results suggest that carbonic anhydrase could be involved in generating the PD between CSF and blood.",

author = "Davies, \{D. G.\} and Britton, \{S. L.\} and Gurtner, \{G. H.\} and Dutton, \{R. E.\} and Krasney, \{J. A.\}",

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T1 - Effect of carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid and blood

AU - Davies, D. G.

AU - Britton, S. L.

AU - Gurtner, G. H.

AU - Dutton, R. E.

AU - Krasney, J. A.

PY - 1984/10

Y1 - 1984/10

N2 - The effect of cerebral carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid (CSF) and blood (PD) was studied in anesthetized dogs by perfusing the ventriculocisternal system with artificial CSF containing the carbonic anhydrase inhibitor, acetazolamide. The slope of the PD vs. arterial blood pH ( ΔPD ΔpHa) was calculated from PD and pHa values obtained during room-air breathing, respiratory acidosis, and respiratory alkalosis. ΔPD ΔpHa decreased from -26.3 ± 1.9 millivolts per pH unit ( mV U) before acetazolamide administration to 17.6 ± 2.1 after acetazolamide (P < 0.02). The PD at pH 7.4 (PD7.4) increased slightly from 2.9 ± 0.5 mV before acetazolamide treatment to 3.9 ± 0.6 after acetazolamide (P < 0.02). The results suggest that carbonic anhydrase could be involved in generating the PD between CSF and blood.

AB - The effect of cerebral carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid (CSF) and blood (PD) was studied in anesthetized dogs by perfusing the ventriculocisternal system with artificial CSF containing the carbonic anhydrase inhibitor, acetazolamide. The slope of the PD vs. arterial blood pH ( ΔPD ΔpHa) was calculated from PD and pHa values obtained during room-air breathing, respiratory acidosis, and respiratory alkalosis. ΔPD ΔpHa decreased from -26.3 ± 1.9 millivolts per pH unit ( mV U) before acetazolamide administration to 17.6 ± 2.1 after acetazolamide (P < 0.02). The PD at pH 7.4 (PD7.4) increased slightly from 2.9 ± 0.5 mV before acetazolamide treatment to 3.9 ± 0.6 after acetazolamide (P < 0.02). The results suggest that carbonic anhydrase could be involved in generating the PD between CSF and blood.

UR - https://www.scopus.com/pages/publications/0021711554

U2 - 10.1016/0014-4886(84)90067-0

DO - 10.1016/0014-4886(84)90067-0

M3 - Article

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AN - SCOPUS:0021711554

SN - 0014-4886

VL - 86

SP - 66

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JO - Experimental Neurology

JF - Experimental Neurology

IS - 1

ER -

Effect of carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid and blood

Abstract

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