Effect of 71 ATA He-O2 on organ blood flow in the rat

L. Aanderud; J. Onarheim; I. Tyssebotn

doi:10.1152/jappl.1985.59.5.1369

Effect of 71 ATA He-O₂ on organ blood flow in the rat

L. Aanderud
, J. Onarheim
, I. Tyssebotn

Physiology and Biophysics

University Hospital of North Norway

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cardiac output and organ blood flow to major organs were investigated in awake rats at 1 atmosphere absolute (ATA) air and at 71 ATA He-O₂. Radioactively labeled microspheres [15 ± 1 (SD) μm] were injected into the left ventricle during constant-rate arterial blood sampling at 1 ATA air and subsequently at 71 ATA He-O₂. Intra-arterial blood pressure was continuously recorded. The partial pressure of O₂ was kept between 0.4 and 0.6 ATA. The results indicate that the mean blood pressure, heart rate, cardiac output, and organ blood flow are essentially unaltered in the rat at 71 ATA except for increased blood flow to the liver (122%, P< 0.05), whereas the blood flow to the adrenals, the diaphragm, and the leg muscle fell (P<0.05).

Original language	English
Pages (from-to)	1369-1375
Number of pages	7
Journal	Journal of Applied Physiology
Volume	59
Issue number	5
DOIs	https://doi.org/10.1152/jappl.1985.59.5.1369
State	Published - 1985

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10.1152/jappl.1985.59.5.1369

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title = "Effect of 71 ATA He-O2 on organ blood flow in the rat",

abstract = "Cardiac output and organ blood flow to major organs were investigated in awake rats at 1 atmosphere absolute (ATA) air and at 71 ATA He-O2. Radioactively labeled microspheres [15 ± 1 (SD) μm] were injected into the left ventricle during constant-rate arterial blood sampling at 1 ATA air and subsequently at 71 ATA He-O2. Intra-arterial blood pressure was continuously recorded. The partial pressure of O2 was kept between 0.4 and 0.6 ATA. The results indicate that the mean blood pressure, heart rate, cardiac output, and organ blood flow are essentially unaltered in the rat at 71 ATA except for increased blood flow to the liver (122\%, P< 0.05), whereas the blood flow to the adrenals, the diaphragm, and the leg muscle fell (P<0.05).",

author = "L. Aanderud and J. Onarheim and I. Tyssebotn",

year = "1985",

doi = "10.1152/jappl.1985.59.5.1369",

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T1 - Effect of 71 ATA He-O2 on organ blood flow in the rat

AU - Aanderud, L.

AU - Onarheim, J.

AU - Tyssebotn, I.

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AB - Cardiac output and organ blood flow to major organs were investigated in awake rats at 1 atmosphere absolute (ATA) air and at 71 ATA He-O2. Radioactively labeled microspheres [15 ± 1 (SD) μm] were injected into the left ventricle during constant-rate arterial blood sampling at 1 ATA air and subsequently at 71 ATA He-O2. Intra-arterial blood pressure was continuously recorded. The partial pressure of O2 was kept between 0.4 and 0.6 ATA. The results indicate that the mean blood pressure, heart rate, cardiac output, and organ blood flow are essentially unaltered in the rat at 71 ATA except for increased blood flow to the liver (122%, P< 0.05), whereas the blood flow to the adrenals, the diaphragm, and the leg muscle fell (P<0.05).

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Effect of 71 ATA He-O₂ on organ blood flow in the rat

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