Early experience with meropenem- vaborbactam for treatment of carbapenem-resistant enterobacteriaceae infections

Ryan K. Shields; Erin K. McCreary; Rachel V. Marini; Ellen G. Kline; Chelsea E. Jones; Binghua Hao; Liang Chen; Barry N. Kreiswirth; Yohei Doi; Cornelius J. Clancy; M. Hong Nguyen

doi:10.1093/cid/ciz1131

Early experience with meropenem- vaborbactam for treatment of carbapenem-resistant enterobacteriaceae infections

Ryan K. Shields
, Erin K. McCreary
, Rachel V. Marini
, Ellen G. Kline
, Chelsea E. Jones
, Binghua Hao
, Liang Chen
, Barry N. Kreiswirth
, Yohei Doi
, Cornelius J. Clancy
, M. Hong Nguyen

Pharmacy

University of Pittsburgh
Hackensack Meridian Health
VA Medical Center

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Twenty patients with carbapenem-resistant Enterobacteriaceae infections were treated with meropenem-vaborbactam. Thirtyday clinical success and survival rates were 65% (13/20) and 90% (18/20), respectively. Thirty-five percent of patients had microbiologic failures within 90 days. One patient developed a recurrent infection due to meropenem-vaborbactam- nonsusceptible, ompK36 porin mutant Klebsiella pneumoniae.

Original language	English
Pages (from-to)	667-671
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	71
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciz1131
State	Published - Aug 1 2020

Keywords

KPC
Meropenem
P orin
Resistance
Vaborbactam

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10.1093/cid/ciz1131

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title = "Early experience with meropenem- vaborbactam for treatment of carbapenem-resistant enterobacteriaceae infections",

abstract = "Twenty patients with carbapenem-resistant Enterobacteriaceae infections were treated with meropenem-vaborbactam. Thirtyday clinical success and survival rates were 65\% (13/20) and 90\% (18/20), respectively. Thirty-five percent of patients had microbiologic failures within 90 days. One patient developed a recurrent infection due to meropenem-vaborbactam- nonsusceptible, ompK36 porin mutant Klebsiella pneumoniae.",

keywords = "KPC, Meropenem, P orin, Resistance, Vaborbactam",

author = "Shields, \{Ryan K.\} and McCreary, \{Erin K.\} and Marini, \{Rachel V.\} and Kline, \{Ellen G.\} and Jones, \{Chelsea E.\} and Binghua Hao and Liang Chen and Kreiswirth, \{Barry N.\} and Yohei Doi and Clancy, \{Cornelius J.\} and Nguyen, \{M. Hong\}",

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doi = "10.1093/cid/ciz1131",

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T1 - Early experience with meropenem- vaborbactam for treatment of carbapenem-resistant enterobacteriaceae infections

AU - Shields, Ryan K.

AU - McCreary, Erin K.

AU - Marini, Rachel V.

AU - Kline, Ellen G.

AU - Jones, Chelsea E.

AU - Hao, Binghua

AU - Chen, Liang

AU - Kreiswirth, Barry N.

AU - Doi, Yohei

AU - Clancy, Cornelius J.

AU - Nguyen, M. Hong

N1 - Publisher Copyright: © The Author(s) 2019.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Twenty patients with carbapenem-resistant Enterobacteriaceae infections were treated with meropenem-vaborbactam. Thirtyday clinical success and survival rates were 65% (13/20) and 90% (18/20), respectively. Thirty-five percent of patients had microbiologic failures within 90 days. One patient developed a recurrent infection due to meropenem-vaborbactam- nonsusceptible, ompK36 porin mutant Klebsiella pneumoniae.

AB - Twenty patients with carbapenem-resistant Enterobacteriaceae infections were treated with meropenem-vaborbactam. Thirtyday clinical success and survival rates were 65% (13/20) and 90% (18/20), respectively. Thirty-five percent of patients had microbiologic failures within 90 days. One patient developed a recurrent infection due to meropenem-vaborbactam- nonsusceptible, ompK36 porin mutant Klebsiella pneumoniae.

KW - KPC

KW - Meropenem

KW - P orin

KW - Resistance

KW - Vaborbactam

UR - https://www.scopus.com/pages/publications/85088848147

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DO - 10.1093/cid/ciz1131

M3 - Article

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AN - SCOPUS:85088848147

SN - 1058-4838

VL - 71

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

Early experience with meropenem- vaborbactam for treatment of carbapenem-resistant enterobacteriaceae infections

Abstract

Keywords

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