(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: Synthesis, cytotoxic activity and antitumor activity

Young Jae You; Yong Kim; Gyu Yong Song; Byung Zun Ahn

doi:10.1016/S0960-894X(00)00447-9

(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: Synthesis, cytotoxic activity and antitumor activity

Young Jae You
, Yong Kim
, Gyu Yong Song
, Byung Zun Ahn

Pharmaceutical Sciences

Chungnam National University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED₅₀ values, ranging from 0.1 to 0.3 μg/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%). (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2301-2303
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(00)00447-9
State	Published - Oct 16 2000

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title = "(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: Synthesis, cytotoxic activity and antitumor activity",

abstract = "All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (\%) values (318-388\%) than Adriamycin (T/C, 315\%). (C) 2000 Elsevier Science Ltd.",

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T1 - (E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones

T2 - Synthesis, cytotoxic activity and antitumor activity

AU - You, Young Jae

AU - Kim, Yong

AU - Song, Gyu Yong

AU - Ahn, Byung Zun

PY - 2000/10/16

Y1 - 2000/10/16

N2 - All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%). (C) 2000 Elsevier Science Ltd.

AB - All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%). (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034675754

U2 - 10.1016/S0960-894X(00)00447-9

DO - 10.1016/S0960-894X(00)00447-9

M3 - Article

C2 - 11055343

AN - SCOPUS:0034675754

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 20

ER -

(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: Synthesis, cytotoxic activity and antitumor activity

Abstract

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