Drug signals enhance morphine tolerance development in hypophysectomized rats

Stephen T. Tiffany; Eric C. Petrie; Eileen M. Martin; Timothy B. Baker

doi:10.1007/BF00433022

Drug signals enhance morphine tolerance development in hypophysectomized rats

Stephen T. Tiffany
, Eric C. Petrie
, Eileen M. Martin
, Timothy B. Baker

Psychology

University of Wisconsin-Madison

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Hypophysectomized and sham-operated (normal) rats were given morphine (5 mg/kg) either paired or unpaired with distinctive environmental cues. Both hypophysectomized and normal animals developed analgesic tolerance when drug effects were signaled, but little tolerance was evident in either surgery group when drug was unsignaled. Results suggest that the pituitary is not critical to associational tolerance development.

Original language	English
Pages (from-to)	84-85
Number of pages	2
Journal	Psychopharmacology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1007/BF00433022
State	Published - Jan 1983

Keywords

Analgesia
Hypophysectomy
Morphine tolerance
Pavlovian learning
Pituitary
Stress-induced antinociception

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10.1007/BF00433022

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abstract = "Hypophysectomized and sham-operated (normal) rats were given morphine (5 mg/kg) either paired or unpaired with distinctive environmental cues. Both hypophysectomized and normal animals developed analgesic tolerance when drug effects were signaled, but little tolerance was evident in either surgery group when drug was unsignaled. Results suggest that the pituitary is not critical to associational tolerance development.",

keywords = "Analgesia, Hypophysectomy, Morphine tolerance, Pavlovian learning, Pituitary, Stress-induced antinociception",

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AU - Martin, Eileen M.

AU - Baker, Timothy B.

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AB - Hypophysectomized and sham-operated (normal) rats were given morphine (5 mg/kg) either paired or unpaired with distinctive environmental cues. Both hypophysectomized and normal animals developed analgesic tolerance when drug effects were signaled, but little tolerance was evident in either surgery group when drug was unsignaled. Results suggest that the pituitary is not critical to associational tolerance development.

KW - Analgesia

KW - Hypophysectomy

KW - Morphine tolerance

KW - Pavlovian learning

KW - Pituitary

KW - Stress-induced antinociception

UR - https://www.scopus.com/pages/publications/0020680842

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ER -

Drug signals enhance morphine tolerance development in hypophysectomized rats

Abstract

Keywords

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