Drug removal by plasmapheresis: An evidence-based review

Rami B. Ibrahim; Chin Liu; Simon M. Cronin; Bridgette C. Murphy; Raymond Cha; Paul Swerdlow; David J. Edwards

doi:10.1592/phco.27.11.1529

Drug removal by plasmapheresis: An evidence-based review

Rami B. Ibrahim
, Chin Liu
, Simon M. Cronin
, Bridgette C. Murphy
, Raymond Cha
, Paul Swerdlow
, David J. Edwards

Pharmacy

Wayne State University
Borgess Health

Research output: Contribution to journal › Review article › peer-review

119 Scopus citations

Abstract

Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications - mostly case reports of overdoses - have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.

Original language	English
Pages (from-to)	1529-1549
Number of pages	21
Journal	Pharmacotherapy
Volume	27
Issue number	11
DOIs	https://doi.org/10.1592/phco.27.11.1529
State	Published - Nov 2007

Keywords

Apheresis
Drug removal
Pharmacokinetics
Plasma exchange
Plasmapheresis

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title = "Drug removal by plasmapheresis: An evidence-based review",

abstract = "Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications - mostly case reports of overdoses - have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.",

keywords = "Apheresis, Drug removal, Pharmacokinetics, Plasma exchange, Plasmapheresis",

author = "Ibrahim, \{Rami B.\} and Chin Liu and Cronin, \{Simon M.\} and Murphy, \{Bridgette C.\} and Raymond Cha and Paul Swerdlow and Edwards, \{David J.\}",

year = "2007",

month = nov,

doi = "10.1592/phco.27.11.1529",

language = "English",

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journal = "Pharmacotherapy",

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publisher = "American College of Clinical Pharmacy",

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T2 - An evidence-based review

AU - Ibrahim, Rami B.

AU - Liu, Chin

AU - Cronin, Simon M.

AU - Murphy, Bridgette C.

AU - Cha, Raymond

AU - Swerdlow, Paul

AU - Edwards, David J.

PY - 2007/11

Y1 - 2007/11

N2 - Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications - mostly case reports of overdoses - have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.

AB - Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications - mostly case reports of overdoses - have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.

KW - Apheresis

KW - Drug removal

KW - Pharmacokinetics

KW - Plasma exchange

KW - Plasmapheresis

UR - https://www.scopus.com/pages/publications/35848929491

U2 - 10.1592/phco.27.11.1529

DO - 10.1592/phco.27.11.1529

M3 - Review article

C2 - 17963462

AN - SCOPUS:35848929491

SN - 0277-0008

VL - 27

SP - 1529

EP - 1549

JO - Pharmacotherapy

JF - Pharmacotherapy

IS - 11

ER -

Drug removal by plasmapheresis: An evidence-based review

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Keywords

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