Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems

Haiyung Cheng; William J. Jusko

doi:10.1002/bdd.2510120108

Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems

Haiyung Cheng
, William J. Jusko

Pharmaceutical Sciences

SUNY Buffalo
Merrell Dow Pharmaceuticals, Inc.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Equations for the mean number of cycles through the peripheral system (R) and the mean transit time through the central compartment (MTT_c) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. This R is a function of distribution clearance (CL_D), dose, and area under the plasma concentration–time curve (AUC). The MTT_c is a function of the central volume of distribution, CL_D, dose, and AUC. The application of the proposed calculations of R and MTT_c was illustrated by computer simulations.

Original language	English
Pages (from-to)	73-79
Number of pages	7
Journal	Biopharmaceutics and Drug Disposition
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/bdd.2510120108
State	Published - 1991

Keywords

Concentration‐average clearance
Disposition decomposition analysis
Drug redistribution
Mean number of cycles through the peripheral system
Mean transit time

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10.1002/bdd.2510120108

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abstract = "Equations for the mean number of cycles through the peripheral system (R) and the mean transit time through the central compartment (MTTc) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. This R is a function of distribution clearance (CLD), dose, and area under the plasma concentration–time curve (AUC). The MTTc is a function of the central volume of distribution, CLD, dose, and AUC. The application of the proposed calculations of R and MTTc was illustrated by computer simulations.",

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T1 - Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems

AU - Cheng, Haiyung

AU - Jusko, William J.

PY - 1991

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N2 - Equations for the mean number of cycles through the peripheral system (R) and the mean transit time through the central compartment (MTTc) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. This R is a function of distribution clearance (CLD), dose, and area under the plasma concentration–time curve (AUC). The MTTc is a function of the central volume of distribution, CLD, dose, and AUC. The application of the proposed calculations of R and MTTc was illustrated by computer simulations.

AB - Equations for the mean number of cycles through the peripheral system (R) and the mean transit time through the central compartment (MTTc) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. This R is a function of distribution clearance (CLD), dose, and area under the plasma concentration–time curve (AUC). The MTTc is a function of the central volume of distribution, CLD, dose, and AUC. The application of the proposed calculations of R and MTTc was illustrated by computer simulations.

KW - Concentration‐average clearance

KW - Disposition decomposition analysis

KW - Drug redistribution

KW - Mean number of cycles through the peripheral system

KW - Mean transit time

UR - https://www.scopus.com/pages/publications/0025967339

U2 - 10.1002/bdd.2510120108

DO - 10.1002/bdd.2510120108

M3 - Review article

C2 - 2039813

AN - SCOPUS:0025967339

SN - 0142-2782

VL - 12

SP - 73

EP - 79

JO - Biopharmaceutics and Drug Disposition

JF - Biopharmaceutics and Drug Disposition

IS - 1

ER -

Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems

Abstract

Keywords

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