Dissecting the biophysics and biology of intrinsically disordered proteins

Priya R. Banerjee; Alex S. Holehouse; Richard Kriwacki; Paul Robustelli; Hao Jiang; Alexander I. Sobolevsky; Jennifer M. Hurley; Joshua T. Mendell

doi:10.1016/j.tibs.2023.10.002

Dissecting the biophysics and biology of intrinsically disordered proteins

Priya R. Banerjee
, Alex S. Holehouse
, Richard Kriwacki
, Paul Robustelli
, Hao Jiang
, Alexander I. Sobolevsky
, Jennifer M. Hurley
, Joshua T. Mendell

Physics

Washington University St. Louis
St. Jude Children Research Hospital
Dartmouth College
University of Virginia
Columbia University
Rensselaer Polytechnic Institute
Howard Hughes Medical Institute

Research output: Contribution to journal › Comment/debate

17 Scopus citations

Abstract

Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/j.tibs.2023.10.002
State	Published - Feb 2024

Keywords

cancer
condensates
phase separation
single-molecule microscopy

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10.1016/j.tibs.2023.10.002

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title = "Dissecting the biophysics and biology of intrinsically disordered proteins",

abstract = "Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.",

keywords = "cancer, condensates, phase separation, single-molecule microscopy",

author = "Banerjee, \{Priya R.\} and Holehouse, \{Alex S.\} and Richard Kriwacki and Paul Robustelli and Hao Jiang and Sobolevsky, \{Alexander I.\} and Hurley, \{Jennifer M.\} and Mendell, \{Joshua T.\}",

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T1 - Dissecting the biophysics and biology of intrinsically disordered proteins

AU - Banerjee, Priya R.

AU - Holehouse, Alex S.

AU - Kriwacki, Richard

AU - Robustelli, Paul

AU - Jiang, Hao

AU - Sobolevsky, Alexander I.

AU - Hurley, Jennifer M.

AU - Mendell, Joshua T.

PY - 2024/2

Y1 - 2024/2

N2 - Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

AB - Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

KW - cancer

KW - condensates

KW - phase separation

KW - single-molecule microscopy

UR - https://www.scopus.com/pages/publications/85176232450

U2 - 10.1016/j.tibs.2023.10.002

DO - 10.1016/j.tibs.2023.10.002

M3 - Comment/debate

C2 - 37949765

AN - SCOPUS:85176232450

SN - 0968-0004

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SP - 101

EP - 104

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 2

ER -

Dissecting the biophysics and biology of intrinsically disordered proteins

Abstract

Keywords

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