Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Yen Wei; George L. Mc Lendon; Andrew D. Hamilton; Martin A. Case; Cherie B. Purring; Qing Lin; Hyung Soon Park; Chang Sun Leec; Tianning Yua

doi:10.1039/b104142h

Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Yen Wei
, George L. Mc Lendon
, Andrew D. Hamilton
, Martin A. Case
, Cherie B. Purring
, Qing Lin
, Hyung Soon Park
, Chang Sun Leec
, Tianning Yua

Chemistry

Princeton University
Drexel University
Yale University

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 10⁸ M⁻¹, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.

Original language	English
Pages (from-to)	1580-1581
Number of pages	2
Journal	Chemical Communications
Volume	1
Issue number	17
DOIs	https://doi.org/10.1039/b104142h
State	Published - 2001

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title = "Disruption of protein{\textendash}protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase",

abstract = "Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) {\texttimes} 108 M−1, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.",

author = "Yen Wei and \{Mc Lendon\}, \{George L.\} and Hamilton, \{Andrew D.\} and Case, \{Martin A.\} and Purring, \{Cherie B.\} and Qing Lin and Park, \{Hyung Soon\} and Leec, \{Chang Sun\} and Tianning Yua",

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doi = "10.1039/b104142h",

language = "English",

volume = "1",

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T1 - Disruption of protein–protein interactions

T2 - Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

AU - Wei, Yen

AU - Mc Lendon, George L.

AU - Hamilton, Andrew D.

AU - Case, Martin A.

AU - Purring, Cherie B.

AU - Lin, Qing

AU - Park, Hyung Soon

AU - Leec, Chang Sun

AU - Yua, Tianning

PY - 2001

Y1 - 2001

N2 - Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.

AB - Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.

UR - https://www.scopus.com/pages/publications/0035823391

U2 - 10.1039/b104142h

DO - 10.1039/b104142h

M3 - Article

C2 - 12240391

AN - SCOPUS:0035823391

SN - 1359-7345

VL - 1

SP - 1580

EP - 1581

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Abstract

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