Direct access to neoglycoproteins and glycopolymers from single precursors. Synthesis of T-antigen and N-acetyl-lactosamine-β-D-(1→6)-α-D-GalNAc conjugates

René Roy; François D. Tropper; Anna Romanowska; Rakesh K. Jain; C. F. Piskorz; Khushi L. Matta

doi:10.1016/S0960-894X(00)80586-7

Direct access to neoglycoproteins and glycopolymers from single precursors. Synthesis of T-antigen and N-acetyl-lactosamine-β-D-(1→6)-α-D-GalNAc conjugates

René Roy
, François D. Tropper
, Anna Romanowska
, Rakesh K. Jain
, C. F. Piskorz
, Khushi L. Matta

Department of Chemical and Biological Engineering

University of Ottawa
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Michael addition and acrylamide copolymerization of single N-acryloylated carbohydrate precursors of the Thomsen Friedenreich antigen (T-antigen) and an ABH type 2 human blood group trisaccharide determinant afforded both neoglycoprotein and glycopolymer conjugates suitable for immunochemical studies.

Original language	English
Pages (from-to)	911-914
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(00)80586-7
State	Published - Sep 1992

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title = "Direct access to neoglycoproteins and glycopolymers from single precursors. Synthesis of T-antigen and N-acetyl-lactosamine-β-D-(1→6)-α-D-GalNAc conjugates",

abstract = "Michael addition and acrylamide copolymerization of single N-acryloylated carbohydrate precursors of the Thomsen Friedenreich antigen (T-antigen) and an ABH type 2 human blood group trisaccharide determinant afforded both neoglycoprotein and glycopolymer conjugates suitable for immunochemical studies.",

author = "Ren{\'e} Roy and Tropper, \{Fran{\c c}ois D.\} and Anna Romanowska and Jain, \{Rakesh K.\} and Piskorz, \{C. F.\} and Matta, \{Khushi L.\}",

year = "1992",

month = sep,

doi = "10.1016/S0960-894X(00)80586-7",

language = "English",

volume = "2",

pages = "911--914",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "9",

}

Direct access to neoglycoproteins and glycopolymers from single precursors. Synthesis of T-antigen and N-acetyl-lactosamine-β-D-(1→6)-α-D-GalNAc conjugates. / Roy, René; Tropper, François D.; Romanowska, Anna et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 2, No. 9, 09.1992, p. 911-914.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Direct access to neoglycoproteins and glycopolymers from single precursors. Synthesis of T-antigen and N-acetyl-lactosamine-β-D-(1→6)-α-D-GalNAc conjugates

AU - Roy, René

AU - Tropper, François D.

AU - Romanowska, Anna

AU - Jain, Rakesh K.

AU - Piskorz, C. F.

AU - Matta, Khushi L.

PY - 1992/9

Y1 - 1992/9

N2 - Michael addition and acrylamide copolymerization of single N-acryloylated carbohydrate precursors of the Thomsen Friedenreich antigen (T-antigen) and an ABH type 2 human blood group trisaccharide determinant afforded both neoglycoprotein and glycopolymer conjugates suitable for immunochemical studies.

AB - Michael addition and acrylamide copolymerization of single N-acryloylated carbohydrate precursors of the Thomsen Friedenreich antigen (T-antigen) and an ABH type 2 human blood group trisaccharide determinant afforded both neoglycoprotein and glycopolymer conjugates suitable for immunochemical studies.

UR - https://www.scopus.com/pages/publications/0026486330

U2 - 10.1016/S0960-894X(00)80586-7

DO - 10.1016/S0960-894X(00)80586-7

M3 - Article

AN - SCOPUS:0026486330

SN - 0960-894X

VL - 2

SP - 911

EP - 914

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Direct access to neoglycoproteins and glycopolymers from single precursors. Synthesis of T-antigen and N-acetyl-lactosamine-β-D-(1→6)-α-D-GalNAc conjugates

Abstract

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