Diphosphonates inhibit human osteoblast secretion and proliferation

M. A. Khokher; P. Dandona

doi:10.1016/0026-0495(89)90260-6

Diphosphonates inhibit human osteoblast secretion and proliferation

M. A. Khokher
, P. Dandona

Medicine

Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

In view of the beneficial effect of diphosphanates in Paget's disease and their suppressive effect on alkaline phosphatase, the action of three diphosphonates (aminohydroxypropylidene diphosphonate [APD], clodronate, and didronel) on cultured human osteoblasts in vitro was investigated. All three inhibited basal and 1,25(OH)₂ cholecalciferol-stimulated alkaline phosphatase secretion and [³H]thymidine uptake by osteoblasts. It is concluded that diphosphonates consistently inhibit human osteoblasts through a direct action in addition to their known effect on inhibiting bone resorption and that these actions together may form the basis of their beneficial effect in vivo in patients with Paget's disease.

Original language	English
Pages (from-to)	184-187
Number of pages	4
Journal	Metabolism: Clinical and Experimental
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/0026-0495(89)90260-6
State	Published - Feb 1989

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title = "Diphosphonates inhibit human osteoblast secretion and proliferation",

abstract = "In view of the beneficial effect of diphosphanates in Paget's disease and their suppressive effect on alkaline phosphatase, the action of three diphosphonates (aminohydroxypropylidene diphosphonate [APD], clodronate, and didronel) on cultured human osteoblasts in vitro was investigated. All three inhibited basal and 1,25(OH)2 cholecalciferol-stimulated alkaline phosphatase secretion and [3H]thymidine uptake by osteoblasts. It is concluded that diphosphonates consistently inhibit human osteoblasts through a direct action in addition to their known effect on inhibiting bone resorption and that these actions together may form the basis of their beneficial effect in vivo in patients with Paget's disease.",

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AU - Khokher, M. A.

AU - Dandona, P.

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N2 - In view of the beneficial effect of diphosphanates in Paget's disease and their suppressive effect on alkaline phosphatase, the action of three diphosphonates (aminohydroxypropylidene diphosphonate [APD], clodronate, and didronel) on cultured human osteoblasts in vitro was investigated. All three inhibited basal and 1,25(OH)2 cholecalciferol-stimulated alkaline phosphatase secretion and [3H]thymidine uptake by osteoblasts. It is concluded that diphosphonates consistently inhibit human osteoblasts through a direct action in addition to their known effect on inhibiting bone resorption and that these actions together may form the basis of their beneficial effect in vivo in patients with Paget's disease.

AB - In view of the beneficial effect of diphosphanates in Paget's disease and their suppressive effect on alkaline phosphatase, the action of three diphosphonates (aminohydroxypropylidene diphosphonate [APD], clodronate, and didronel) on cultured human osteoblasts in vitro was investigated. All three inhibited basal and 1,25(OH)2 cholecalciferol-stimulated alkaline phosphatase secretion and [3H]thymidine uptake by osteoblasts. It is concluded that diphosphonates consistently inhibit human osteoblasts through a direct action in addition to their known effect on inhibiting bone resorption and that these actions together may form the basis of their beneficial effect in vivo in patients with Paget's disease.

UR - https://www.scopus.com/pages/publications/0024494133

U2 - 10.1016/0026-0495(89)90260-6

DO - 10.1016/0026-0495(89)90260-6

M3 - Article

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AN - SCOPUS:0024494133

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VL - 38

SP - 184

EP - 187

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 2

ER -

Diphosphonates inhibit human osteoblast secretion and proliferation

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