Developmental toxicity of 2,3,7,8-TCDD in the rat and hamster

James R. Olson; Barbara P. McGarrigle; David A. Tonucci; Arnold Schecter; Henry Eichelberger

doi:10.1016/0045-6535(90)90230-Q

Developmental toxicity of 2,3,7,8-TCDD in the rat and hamster

James R. Olson
, Barbara P. McGarrigle
, David A. Tonucci
, Arnold Schecter
, Henry Eichelberger

Department of Epidemiology and Environmental Health

SUNY Buffalo
SUNY Upstate Medical University
State University of New York Binghamton University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

In mature animals the acute toxicity of 2,3,7,8-TCDD exhibits marked interspecies variability. The developmental toxicity of 2,3,7,8-TCDD was assessed in the rat and hamster to investigate potential interspecies variability in the embryotoxicity and teratogenicity of TCDD. Although there are species differences in the expression of fetal toxicity, the results suggest that the toxic potency of TCDD is similar in the developing rat and hamster.

Original language	English
Pages (from-to)	1117-1123
Number of pages	7
Journal	Chemosphere
Volume	20
Issue number	7-9
DOIs	https://doi.org/10.1016/0045-6535(90)90230-Q
State	Published - 1990

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10.1016/0045-6535(90)90230-Q

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title = "Developmental toxicity of 2,3,7,8-TCDD in the rat and hamster",

abstract = "In mature animals the acute toxicity of 2,3,7,8-TCDD exhibits marked interspecies variability. The developmental toxicity of 2,3,7,8-TCDD was assessed in the rat and hamster to investigate potential interspecies variability in the embryotoxicity and teratogenicity of TCDD. Although there are species differences in the expression of fetal toxicity, the results suggest that the toxic potency of TCDD is similar in the developing rat and hamster.",

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T1 - Developmental toxicity of 2,3,7,8-TCDD in the rat and hamster

AU - Olson, James R.

AU - McGarrigle, Barbara P.

AU - Tonucci, David A.

AU - Schecter, Arnold

AU - Eichelberger, Henry

PY - 1990

Y1 - 1990

N2 - In mature animals the acute toxicity of 2,3,7,8-TCDD exhibits marked interspecies variability. The developmental toxicity of 2,3,7,8-TCDD was assessed in the rat and hamster to investigate potential interspecies variability in the embryotoxicity and teratogenicity of TCDD. Although there are species differences in the expression of fetal toxicity, the results suggest that the toxic potency of TCDD is similar in the developing rat and hamster.

AB - In mature animals the acute toxicity of 2,3,7,8-TCDD exhibits marked interspecies variability. The developmental toxicity of 2,3,7,8-TCDD was assessed in the rat and hamster to investigate potential interspecies variability in the embryotoxicity and teratogenicity of TCDD. Although there are species differences in the expression of fetal toxicity, the results suggest that the toxic potency of TCDD is similar in the developing rat and hamster.

UR - https://www.scopus.com/pages/publications/0025046053

U2 - 10.1016/0045-6535(90)90230-Q

DO - 10.1016/0045-6535(90)90230-Q

M3 - Article

AN - SCOPUS:0025046053

SN - 0045-6535

VL - 20

SP - 1117

EP - 1123

JO - Chemosphere

JF - Chemosphere

IS - 7-9

ER -

Developmental toxicity of 2,3,7,8-TCDD in the rat and hamster

Abstract

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