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Development of the summary of findings table for network meta-analysis

  • Juan José Yepes-Nuñez
  • , Shelly Anne Li
  • , Gordon Guyatt
  • , Susan M. Jack
  • , Jan L. Brozek
  • , Joseph Beyene
  • , M. Hassan Murad
  • , Bram Rochwerg
  • , Lawrence Mbuagbaw
  • , Yuan Zhang
  • , Ivan D. Flórez
  • , Reed A. Siemieniuk
  • , Behnam Sadeghirad
  • , Reem Mustafa
  • , Nancy Santesso
  • , Holger J. Schünemann
  • McMaster University
  • Universidad de los Andes Colombia
  • University of Toronto
  • Mayo Clinic Rochester, MN
  • University of Kansas

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

Objectives: The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). Study Design and Setting: We applied a user experience model for data analysis based on four rounds of semistructured interviews. Results: We interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings. Conclusion: Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Clinical Epidemiology
Volume115
DOIs
StatePublished - Nov 2019

Keywords

  • Certainty of evidence
  • Decision-making
  • GRADE
  • Network meta-analysis
  • Summary of findings
  • Systematic reviews

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