Design and synthesis of potential new apoptosis agents: hybrid compounds containing perillyl alcohol and new constrained retinoids

Bhaskar C. Das; Sakkarapalayam M. Mahalingam; Lipsa Panda; Bo Wang; Phillp D. Campbell; Todd Evans

doi:10.1016/j.tetlet.2010.01.003

Design and synthesis of potential new apoptosis agents: hybrid compounds containing perillyl alcohol and new constrained retinoids

Bhaskar C. Das
, Sakkarapalayam M. Mahalingam
, Lipsa Panda
, Bo Wang
, Phillp D. Campbell
, Todd Evans

Pharmaceutical Sciences

Albert Einstein College of Medicine
Cornell University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N′-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.

Original language	English
Pages (from-to)	1462-1466
Number of pages	5
Journal	Tetrahedron Letters
Volume	51
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2010.01.003
State	Published - Mar 17 2010

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title = "Design and synthesis of potential new apoptosis agents: hybrid compounds containing perillyl alcohol and new constrained retinoids",

abstract = "Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N′-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82\%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.",

author = "Das, \{Bhaskar C.\} and Mahalingam, \{Sakkarapalayam M.\} and Lipsa Panda and Bo Wang and Campbell, \{Phillp D.\} and Todd Evans",

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T1 - Design and synthesis of potential new apoptosis agents

T2 - hybrid compounds containing perillyl alcohol and new constrained retinoids

AU - Das, Bhaskar C.

AU - Mahalingam, Sakkarapalayam M.

AU - Panda, Lipsa

AU - Wang, Bo

AU - Campbell, Phillp D.

AU - Evans, Todd

PY - 2010/3/17

Y1 - 2010/3/17

N2 - Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N′-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.

AB - Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N′-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.

UR - https://www.scopus.com/pages/publications/75749128665

U2 - 10.1016/j.tetlet.2010.01.003

DO - 10.1016/j.tetlet.2010.01.003

M3 - Article

AN - SCOPUS:75749128665

SN - 0040-4039

VL - 51

SP - 1462

EP - 1466

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

Design and synthesis of potential new apoptosis agents: hybrid compounds containing perillyl alcohol and new constrained retinoids

Abstract

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