Design and synthesis of heterocyclic analogues of mycophenolic acid as potential chemotherapeutic agents

Jeewoo Lee; Wayne K. Anderson

doi:10.1016/0960-894X(95)00130-L

Design and synthesis of heterocyclic analogues of mycophenolic acid as potential chemotherapeutic agents

Jeewoo Lee
, Wayne K. Anderson

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A series of heterocyclic analogues 3-10 of mycophenolic acid were designed as metabolically stable congeners possibly targeted for inosine monophosphate dehydrogenase. The synthesis, cytotoxic and anti-HIV activity of these compounds are described.

Original language	English
Pages (from-to)	861-866
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/0960-894X(95)00130-L
State	Published - Apr 20 1995

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title = "Design and synthesis of heterocyclic analogues of mycophenolic acid as potential chemotherapeutic agents",

abstract = "A series of heterocyclic analogues 3-10 of mycophenolic acid were designed as metabolically stable congeners possibly targeted for inosine monophosphate dehydrogenase. The synthesis, cytotoxic and anti-HIV activity of these compounds are described.",

author = "Jeewoo Lee and Anderson, \{Wayne K.\}",

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T1 - Design and synthesis of heterocyclic analogues of mycophenolic acid as potential chemotherapeutic agents

AU - Lee, Jeewoo

AU - Anderson, Wayne K.

PY - 1995/4/20

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N2 - A series of heterocyclic analogues 3-10 of mycophenolic acid were designed as metabolically stable congeners possibly targeted for inosine monophosphate dehydrogenase. The synthesis, cytotoxic and anti-HIV activity of these compounds are described.

AB - A series of heterocyclic analogues 3-10 of mycophenolic acid were designed as metabolically stable congeners possibly targeted for inosine monophosphate dehydrogenase. The synthesis, cytotoxic and anti-HIV activity of these compounds are described.

UR - https://www.scopus.com/pages/publications/0028927740

U2 - 10.1016/0960-894X(95)00130-L

DO - 10.1016/0960-894X(95)00130-L

M3 - Article

AN - SCOPUS:0028927740

SN - 0960-894X

VL - 5

SP - 861

EP - 866

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Design and synthesis of heterocyclic analogues of mycophenolic acid as potential chemotherapeutic agents

Abstract

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