Design and synthesis of guanidine-containing novel retinoids

Bhaskar C. Das; Sakkarapalayam M. Mahalingam; Pranoy Mohapatra

doi:10.1016/j.tetlet.2009.08.008

Design and synthesis of guanidine-containing novel retinoids

Bhaskar C. Das
, Sakkarapalayam M. Mahalingam
, Pranoy Mohapatra

Pharmaceutical Sciences

Albert Einstein College of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Guanidine-containing new retinoids 1-4 were synthesized through the addition of guanidine to the activated carboxylic acids (retinoids) promoted by carbonyldiimidazole (CDI). A set of structurally and functionally diverse guanidine derivatives of retinoids were obtained in high yields (78-82%). We are in the process of studying the biological effect of these molecules on retinoic acid signaling pathways.

Original language	English
Pages (from-to)	5860-5863
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	42
DOIs	https://doi.org/10.1016/j.tetlet.2009.08.008
State	Published - Oct 21 2009

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title = "Design and synthesis of guanidine-containing novel retinoids",

abstract = "Guanidine-containing new retinoids 1-4 were synthesized through the addition of guanidine to the activated carboxylic acids (retinoids) promoted by carbonyldiimidazole (CDI). A set of structurally and functionally diverse guanidine derivatives of retinoids were obtained in high yields (78-82\%). We are in the process of studying the biological effect of these molecules on retinoic acid signaling pathways.",

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AU - Das, Bhaskar C.

AU - Mahalingam, Sakkarapalayam M.

AU - Mohapatra, Pranoy

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Y1 - 2009/10/21

N2 - Guanidine-containing new retinoids 1-4 were synthesized through the addition of guanidine to the activated carboxylic acids (retinoids) promoted by carbonyldiimidazole (CDI). A set of structurally and functionally diverse guanidine derivatives of retinoids were obtained in high yields (78-82%). We are in the process of studying the biological effect of these molecules on retinoic acid signaling pathways.

AB - Guanidine-containing new retinoids 1-4 were synthesized through the addition of guanidine to the activated carboxylic acids (retinoids) promoted by carbonyldiimidazole (CDI). A set of structurally and functionally diverse guanidine derivatives of retinoids were obtained in high yields (78-82%). We are in the process of studying the biological effect of these molecules on retinoic acid signaling pathways.

UR - https://www.scopus.com/pages/publications/69249248208

U2 - 10.1016/j.tetlet.2009.08.008

DO - 10.1016/j.tetlet.2009.08.008

M3 - Article

AN - SCOPUS:69249248208

SN - 0040-4039

VL - 50

SP - 5860

EP - 5863

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Design and synthesis of guanidine-containing novel retinoids

Abstract

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